Buy ZENEGRA-50 (Sildenafil Tablets IP) Online

Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine
Formula: C22H30N6O4S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid

ZENEGRA-50

Overview

ZENEGRA-50 is a pharmaceutical medication formulated with Sildenafil Citrate, a powerful active ingredient used primarily to treat erectile dysfunction (ED) in men. Manufactured by Alkem Laboratories, one of the leading pharmaceutical companies, ZENEGRA-50 provides a reliable solution for those experiencing difficulties in achieving or maintaining an erection suitable for sexual intercourse. Each tablet contains 50 mg of Sildenafil Citrate, designed to be both effective and safe when used according to medical guidelines.

Composition and Active Ingredient

The main active ingredient in ZENEGRA-50 is Sildenafil Citrate, a potent phosphodiesterase type 5 (PDE5) inhibitor. This compound works by relaxing the blood vessels in the penis, increasing blood flow during sexual stimulation, which helps in achieving and maintaining an erection. Each tablet of ZENEGRA-50 contains 50 mg of Sildenafil Citrate, formulated in accordance with international pharmacological standards to ensure high efficacy and safety.

Indications

ZENEGRA-50 is indicated for the treatment of erectile dysfunction (ED), which is defined as the inability to attain or sustain an erection adequate for satisfactory sexual performance. Erectile dysfunction can have multiple causes, including psychological, neurological, hormonal, vascular, or a combination of these factors. ZENEGRA-50 is effective in men who experience erectile difficulties, regardless of the underlying cause, provided there is some form of sexual arousal.

Mechanism of Action

The effectiveness of ZENEGRA-50 lies in its active ingredient, Sildenafil Citrate, which is a selective inhibitor of the enzyme phosphodiesterase type 5 (PDE5). Inhibition of PDE5 enhances the effect of nitric oxide (NO) by preventing the degradation of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. When sexual stimulation occurs, the release of NO in the corpus cavernosum binds to the guanylate cyclase receptors, leading to increased levels of cGMP. This results in smooth muscle relaxation in the penile arteries, allowing increased blood flow and engorgement of the erectile tissue, leading to an erection.

Dosage and Administration

The recommended starting dose of ZENEGRA-50 is 50 mg taken orally, approximately one hour before sexual activity. However, the timing of its effect may vary from person to person and can be influenced by factors such as food intake and overall health condition. For some men, the effectiveness of ZENEGRA-50 can be observed as early as 30 minutes after ingestion, while for others, it may take up to an hour.

ZENEGRA-50 should be taken as needed and not more than once in a 24-hour period. The dosage may be adjusted based on individual efficacy and tolerability, with the maximum recommended dose being 100 mg and the minimum 25 mg. It is crucial to follow the prescribed dose to avoid potential side effects.

Contraindications

ZENEGRA-50 is contraindicated in individuals who are hypersensitive to Sildenafil or any other component of the tablet. It should not be used by men who are advised against sexual activity due to cardiovascular risk factors or those with severe heart or liver problems. Additionally, ZENEGRA-50 should not be taken concurrently with nitrates (often prescribed for chest pain) or nitric oxide donors, as this combination can lead to a dangerous drop in blood pressure.

Side Effects

As with any medication, ZENEGRA-50 may cause side effects, although not everyone will experience them. Common side effects include headache, flushing, indigestion, nasal congestion, dizziness, and visual disturbances (such as a blue tinge to vision or blurred vision). These side effects are usually mild to moderate in nature and typically diminish as the body adjusts to the medication.

Serious side effects are rare but can occur. If an erection lasts more than four hours (priapism), or if there is sudden vision loss in one or both eyes, immediate medical attention is required. Sudden hearing loss, chest pain, shortness of breath, or an irregular heartbeat are also serious side effects that necessitate prompt medical evaluation.

Interactions

ZENEGRA-50 may interact with other medications, which can alter its effectiveness or increase the risk of adverse effects. It is essential to inform the healthcare provider of all medications currently being taken, including prescription, over-the-counter drugs, and herbal supplements. Medications that may interact with ZENEGRA-50 include nitrates, alpha-blockers, protease inhibitors (used in the treatment of HIV), certain antifungal medications, and other ED treatments.

Precautions and Warnings

Before taking ZENEGRA-50, it is important to undergo a thorough medical evaluation to determine if ED treatment is appropriate. Individuals with underlying health conditions such as heart disease, kidney or liver dysfunction, or anatomical deformities of the penis should exercise caution when using this medication. Patients should avoid consuming large amounts of alcohol, as this can increase the likelihood of side effects and reduce the effectiveness of the medication.

Additionally, grapefruit juice should be avoided while taking ZENEGRA-50 as it can interfere with the metabolism of Sildenafil, leading to increased plasma levels and a heightened risk of adverse effects.

Storage

Store ZENEGRA-50 in a cool, dry place away from direct sunlight and moisture. Keep the tablets in their original packaging and out of reach of children and pets. Do not use the medication beyond its expiration date, as this may reduce its effectiveness and safety.

Conclusion

ZENEGRA-50 (Sildenafil Tablets IP) by Alkem Laboratories offers a reliable and effective treatment option for men experiencing erectile dysfunction. By enhancing blood flow to the penis, ZENEGRA-50 helps achieve and maintain an erection suitable for sexual intercourse, thereby improving sexual satisfaction and quality of life. As with all medications, it is essential to use ZENEGRA-50 under the guidance of a healthcare professional to ensure safety and efficacy.