Product Overview
Xenical 120mg Hard Capsules, manufactured by Roche, is a prescription medication designed to aid in weight management. Each capsule contains 120 mg of Orlistat, a potent lipase inhibitor. With a pack of 84 capsules, Xenical is an essential tool for those struggling with obesity or overweight conditions who need a pharmaceutical aid in conjunction with a reduced-calorie diet and increased physical activity.
Composition and Formulation
Active Ingredient:
- Orlistat: 120 mg per capsule.
Inactive Ingredients:
- Gelatin
- Microcrystalline cellulose
- Sodium lauryl sulfate
- Magnesium stearate
- Others (for full list, consult the package insert)
Form:
- Hard capsules
Pack Size:
- 84 capsules
Mechanism of Action
Xenical works by inhibiting the activity of gastrointestinal lipases, enzymes responsible for the breakdown of dietary fats into absorbable components. Orlistat, the active ingredient, binds to these enzymes, preventing the hydrolysis of triglycerides into free fatty acids and monoglycerides. As a result, approximately 30% of dietary fat is not absorbed and is excreted through the feces. This reduction in fat absorption contributes to weight loss and helps improve the overall effectiveness of a weight loss regimen.
Indications
Xenical is indicated for:
- Weight Loss: To assist in reducing weight in adults with a body mass index (BMI) of 30 or greater, or in those with a BMI of 27 or greater with related risk factors such as hypertension, diabetes, or dyslipidemia.
- Weight Maintenance: To help maintain weight loss in patients who have already achieved weight reduction through dietary and exercise measures.
Dosage and Administration
Recommended Dosage:
- Adults: One 120 mg capsule taken with each main meal containing fat, up to three times daily. The capsule should be swallowed whole with water during or up to one hour after the meal.
- Missed Dose: If a dose is missed, continue with the next scheduled dose. Do not double the dose to make up for a missed one.
Dietary Recommendations:
- Xenical should be used in conjunction with a nutritionally balanced, calorie-reduced diet.
- The diet should include a balanced distribution of fats, carbohydrates, and proteins.
Contraindications
Xenical should not be used in patients with:
- Known hypersensitivity to Orlistat or any of the excipients.
- Chronic malabsorption syndrome.
- Cholestasis (liver condition that impairs bile flow).
- Pregnant or breastfeeding women.
Warnings and Precautions
- Gastrointestinal Issues: Common side effects include oily spotting, flatulence with discharge, and frequent bowel movements. These are related to the fat not being absorbed and may decrease over time.
- Vitamin Deficiency: Long-term use may impair the absorption of fat-soluble vitamins (A, D, E, and K). Consider supplementation if deficiencies are detected.
- Kidney Stones: Patients with a history of oxalate kidney stones should be monitored for symptoms, as Orlistat may increase the risk of developing these stones.
Drug Interactions
- Anticoagulants: Xenical may enhance the effect of anticoagulants such as warfarin. Monitoring of INR levels is advised.
- Cyclosporine: Orlistat may reduce the absorption of cyclosporine. Administer cyclosporine at least 3 hours before or after taking Xenical.
- Thyroid Medications: Patients on thyroid medications should be monitored as Orlistat may interfere with their effectiveness.
Side Effects
Common side effects of Xenical include:
- Gastrointestinal: Abdominal pain, bloating, and diarrhea.
- Skin: Rash or itching.
- Others: Fatigue, headache.
Uncommon but serious side effects may include:
- Severe Liver Injury: Symptoms may include jaundice (yellowing of the skin or eyes), dark urine, or severe abdominal pain.
- Allergic Reactions: Symptoms such as difficulty breathing, swelling of face, lips, tongue, or throat.
Overdose
In the event of an overdose, symptomatic treatment should be administered. There is no specific antidote for Orlistat overdose. Patients should seek medical attention immediately.
Storage Conditions
- Store at temperatures below 30°C (86°F).
- Keep the capsules in their original packaging to protect from moisture and light.
- Do not use after the expiration date stated on the package.
Patient Information
Patients should be advised to:
- Follow a low-fat diet while taking Xenical to reduce the risk of gastrointestinal side effects.
- Monitor their weight regularly and report any unusual symptoms to their healthcare provider.
- Consult their healthcare provider before starting any new medications or supplements.
Xenical 120mg Hard Capsules is a trusted medication for weight management, offering a scientifically backed method to support weight loss efforts when combined with lifestyle modifications. For further information, consult your healthcare provider or refer to the detailed package insert.
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