Overview:
Tilidin 20x 50/4mg is a potent analgesic medication primarily used for the management of moderate to severe pain. Manufactured by Ratiopharm, a trusted name in pharmaceuticals, this medication combines Tilidine, an opioid analgesic, with Naloxone, an opioid antagonist, to provide effective pain relief while minimizing the risk of abuse and dependency.
Composition:
- Active Ingredients:
- Tilidine Hydrochloride: 50 mg
- Naloxone Hydrochloride: 4 mg
- Inactive Ingredients:
- Lactose Monohydrate
- Microcrystalline Cellulose
- Magnesium Stearate
- Colloidal Anhydrous Silica
- Croscarmellose Sodium
Mechanism of Action:
- Tilidine: This is an opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, thereby altering the perception and response to pain.
- Naloxone: An opioid antagonist included to counteract the effects of opioids if taken in large amounts, reducing the potential for abuse. Naloxone blocks the euphoric effects of Tilidine, helping to prevent addiction and overdose.
Indications:
- Treatment of moderate to severe pain where other pain relievers are not effective or appropriate.
- Suitable for chronic pain management in conditions such as cancer pain, severe musculoskeletal pain, and neuropathic pain.
Dosage and Administration:
- Standard Dosage: One tablet of Tilidin 50/4 mg taken orally every 4-6 hours, depending on the intensity of the pain and the patient’s response to the medication.
- Maximum Dosage: The daily dosage should not exceed 6 tablets (300 mg of Tilidine).
Precautions and Warnings:
- Contraindications:
- Known hypersensitivity to Tilidine, Naloxone, or any other component of the product.
- Respiratory depression.
- Acute or severe bronchial asthma.
- Gastrointestinal obstruction, including paralytic ileus.
- Cautions:
- Use with caution in patients with impaired hepatic or renal function.
- Should not be used in patients with a history of substance abuse.
- Not recommended for use during pregnancy or lactation unless deemed absolutely necessary by a physician.
- May impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.
Side Effects:
- Common Side Effects:
- Nausea and vomiting
- Dizziness
- Sweating
- Constipation
- Serious Side Effects:
- Respiratory depression
- Hypotension
- Seizures
- Allergic reactions
Drug Interactions:
- Potential Interactions:
- Central Nervous System (CNS) depressants (e.g., sedatives, hypnotics, tranquilizers)
- Alcohol
- Other opioid analgesics
- Monoamine oxidase inhibitors (MAOIs)
Storage:
- Store at room temperature between 15-25°C (59-77°F).
- Keep out of reach of children.
- Protect from moisture and light.
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