Roszet (rosuvastatin and ezetimibe) is a combination medication used to lower cholesterol levels in the blood. It is a combination of two different medications: rosuvastatin, a statin, and ezetimibe, a cholesterol absorption inhibitor.
- Rosuvastatin works by blocking an enzyme in the liver that is responsible for making cholesterol.
- Ezetimibe works by blocking the absorption of cholesterol from the small intestine into the bloodstream.
Roszet is approved by the US Food and Drug Administration (FDA) to treat adults with:
- Primary non-familial hyperlipidemia, a condition characterized by high cholesterol levels in the blood.
- Homozygous familial hypercholesterolemia (HoFH), a rare genetic condition that causes very high cholesterol levels in the blood.
Roszet is taken once daily by mouth with or without food. The dose is based on the patient’s cholesterol levels and other medical conditions.
Side effects
The most common side effects of Roszet are:
- Headache
- Muscle pain
- Back pain
- Sinus infection
- Diarrhea
- Nausea
- Vomiting
- Constipation
Roszet can also cause more serious side effects, such as:
- Liver damage
- Kidney damage
- Muscle damage
- Rhabdomyolysis (a breakdown of muscle tissue that can release harmful substances into the bloodstream)
Who should not take Roszet?
Roszet should not be taken by people who are allergic to rosuvastatin, ezetimibe, or any of the other ingredients in Roszet. It should also not be taken by people with:
- Active liver disease
- Severe kidney disease
- Pregnancy
- Breastfeeding
Important safety information
It is important to tell your doctor about all of the medications you are taking before starting Roszet. Roszet can interact with other drugs, such as certain antibiotics, anticonvulsants, and blood thinners.
Roszet should be used with caution in people with liver disease, kidney disease, and diabetes.
Roszet can cause serious side effects, such as liver damage and muscle damage. It is important to monitor your liver and muscle function regularly while taking Roszet.
If you are considering taking Roszet, talk to your doctor about the risks and benefits of the medication.
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