Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
PENEGRA-100
Introduction: Penegra-100 tablets are a prescription medication containing Sildenafil Citrate IP 100 mg. Sildenafil Citrate is a potent vasodilator primarily used to treat erectile dysfunction (ED) in men. It works by increasing blood flow to the penis during sexual stimulation, thereby helping men achieve and maintain an erection.
Composition: Each Penegra-100 tablet contains 100 mg of Sildenafil Citrate IP, a phosphodiesterase type 5 (PDE5) inhibitor.
Mechanism of Action: Sildenafil Citrate works by inhibiting the enzyme PDE5, which regulates blood flow in the penis. During sexual stimulation, nitric oxide is released in the erectile tissue of the penis, which activates the enzyme guanylate cyclase. This results in an increase in cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscles and increases blood flow to the corpus cavernosum of the penis. Enhanced blood flow facilitates an erection, aiding in the treatment of ED.
Indications: Penegra-100 tablets are indicated for the treatment of erectile dysfunction in adult men. It is not intended for use in women or children under 18 years of age.
Dosage and Administration:
- The recommended dose of Penegra-100 is one tablet (100 mg) taken orally approximately 30 to 60 minutes before sexual activity.
- The tablet should be swallowed whole with a glass of water.
- It is advised to avoid consuming high-fat meals or alcohol before taking Penegra-100, as they may reduce the effectiveness of the medication.
- Do not take more than one tablet within a 24-hour period.
Contraindications: Penegra-100 tablets are contraindicated in individuals with a known hypersensitivity to Sildenafil Citrate or any inactive ingredients of the tablet. It should not be used concomitantly with nitrates or nitric oxide donors due to the risk of severe hypotension. Use with caution in patients with cardiovascular disease, anatomical deformities of the penis, or predisposition to priapism.
Adverse Effects: Common adverse effects associated with Penegra-100 include headache, flushing, dyspepsia, nasal congestion, dizziness, and visual disturbances (such as changes in color vision or blurred vision). These effects are usually mild to moderate and transient.
Precautions:
- Use Penegra-100 with caution in patients with a history of cardiovascular disease, bleeding disorders, or active peptic ulcers.
- Avoid driving or operating heavy machinery if experiencing dizziness or visual disturbances after taking Penegra-100.
- Inform healthcare providers about all medications currently being taken, including prescription and over-the-counter medications, herbal supplements, and vitamins.
Storage: Store Penegra-100 tablets at room temperature (20-25°C) in a dry place away from direct sunlight and moisture. Keep out of reach of children and pets.
Packaging: Penegra-100 tablets are packaged in a box containing 4 tablets. Each tablet is individually sealed to maintain potency and safety.
Manufacturer: Penegra-100 tablets are manufactured by Zydus Cadila Healthcare Ltd., adhering to strict quality control measures and pharmaceutical standards.
Conclusion: Penegra-100 tablets provide an effective treatment option for men suffering from erectile dysfunction, offering a reliable way to enhance sexual performance and improve quality of life. It is essential to use this medication under medical supervision to ensure safety and efficacy.
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