Oxlumo (lumasiran) is a prescription medicine used to treat primary hyperoxaluria type 1 (PH1) in children and adults. PH1 is a rare genetic disorder that causes the body to produce too much of a substance called oxalate. Oxaluria can cause kidney stones, damage to the kidneys and other organs, and even death.
Oxlumo works by blocking the production of oxalate in the liver. It is given as an injection under the skin once a month.
How effective is Oxlumo?
In clinical studies, Oxlumo was shown to be effective in reducing oxalate levels in the urine and blood in patients with PH1. It was also shown to improve kidney function and reduce the risk of kidney stones and other complications of PH1.
What are the side effects of Oxlumo?
The most common side effects of Oxlumo are:
- Injection site reactions
- Headache
- Fatigue
- Diarrhea
- Nausea
- Vomiting
- Decreased appetite
- Weight loss
- Muscle pain
- Back pain
Oxlumo can also cause more serious side effects, such as:
- Liver problems
- Kidney problems
- Allergic reactions
- Blood clots
Who should not take Oxlumo?
Oxlumo should not be taken by people who are allergic to lumasiran or any of the other ingredients in Oxlumo. It should also not be taken by people with severe liver disease.
Important safety information
It is important to tell your doctor about all of the medications you are taking before starting Oxlumo. Oxlumo can interact with other drugs, such as blood thinners and statins.
Oxlumo should be used with caution in people with liver disease.
Oxlumo can cause serious side effects, such as liver problems and kidney problems. It is important to monitor your liver and kidney function regularly while taking Oxlumo.
If you are considering taking Oxlumo, talk to your doctor about the risks and benefits of the medication.
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