Nexletol is a prescription medication that contains bempedoic acid, used to help lower cholesterol levels in the blood. It is intended for use in adults who have hypercholesterolemia, a condition characterized by high levels of bad cholesterol, known as low-density lipoprotein (LDL) cholesterol.
Uses:
Nexletol is used as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional LDL cholesterol-lowering.
Storage Conditions:
Nexletol should be stored at room temperature between 68°F and 77°F (20°C to 25°C). The medication should be kept in the original container, away from light and moisture.
Mechanism of Action:
Nexletol works by inhibiting adenosine triphosphate citrate lyase (ACL), an enzyme that is involved in the production of cholesterol. By inhibiting ACL, Nexletol decreases cholesterol production in the liver, resulting in lower levels of LDL cholesterol in the blood.
HOW TO USE:
Nexletol comes in tablet form and is taken orally once a day with or without food. The recommended dosage is 180 mg daily. Patients should follow the instructions on the prescription label and use the medication exactly as directed by their healthcare provider.
Important Safety Information:
• Nexletol is not recommended for use in patients with active liver disease or who are pregnant or breastfeeding.
• The medication may increase the risk of tendon rupture or injury and should be used with caution in patients who participate in vigorous physical activities.
• Nexletol may cause muscle pain or weakness, and patients should notify their healthcare provider if they experience unusual muscle symptoms while taking the medication.
• The medication may also cause an increase in blood uric acid levels leading to gout flares, and patients with a history of gout should be monitored closely.
Indications:
• Nexletol is indicated as an adjunct to diet and maximally tolerated statin therapy to treat adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional LDL cholesterol-lowering.
Precautions:
• Patients with liver disease, alcoholism, or a history of muscle disorders should use Nexletol with caution.
• Patients should avoid consuming grapefruit or grapefruit juice while taking Nexletol as it may increase blood levels of the medication.
Interactions:
• Nexletol may interact with other medications such as anticoagulants, warfarin, and fibrates.
• Patients should inform their healthcare provider of all medications they are taking, including supplements and herbal remedies, before starting treatment with Nexletol.
Contraindications:
• Nexletol is contraindicated in patients with active liver disease, or who are pregnant or breastfeeding.
• The medication should not be used in patients with a history of hypersensitivity to bempedoic acid or any of its components.
Overdose:
In case of an overdose, patients should seek emergency medical attention immediately.
Side Effects:
The most common side effects of Nexletol include upper respiratory tract infection, back pain, abdominal pain, and muscle spasms. Serious side effects may include tendon rupture, liver problems, allergic reactions, and muscle damage. Patients should notify their healthcare provider if they experience any unusual symptoms while taking Nexletol.
In conclusion, Nexletol is a prescription medication used to help lower cholesterol levels in patients with hypercholesterolemia. It works by inhibiting the enzyme ACL, decreasing cholesterol production in the liver, and lowering levels of LDL cholesterol in the blood. Nexletol is taken orally once daily and the dosage is determined by the healthcare provider. Patients should avoid grapefruit or grapefruit juice and inform their healthcare provider of all medications they are taking before starting treatment with Nexletol. It is contraindicated in patients with active liver disease or hypersensitivity to bempedoic acid. Patients should seek emergency medical attention in case of overdose and notify their healthcare provider if they experience any unusual symptoms.
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