Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
MALEGRA-120
Introduction
Malegra-120 is a potent medication designed to combat erectile dysfunction (ED) in men. Manufactured by Sunrise Remedies, this pharmaceutical product contains 120 mg of Sildenafil Citrate, an active ingredient known for its efficacy in enhancing erectile function. Malegra-120 is a higher dose option, catering to individuals who may not have achieved desired results with lower doses of Sildenafil.
What is Sildenafil Citrate?
Sildenafil Citrate, the active ingredient in Malegra-120, is a phosphodiesterase type 5 (PDE5) inhibitor. Initially developed to treat cardiovascular conditions, it was later found to have significant effects on erectile dysfunction. Sildenafil Citrate works by enhancing blood flow to the penile region, thereby facilitating and maintaining an erection during sexual stimulation.
How Does Malegra-120 Work?
The mechanism of action of Malegra-120 involves the inhibition of the PDE5 enzyme, which regulates blood flow in the penis. Under normal circumstances, sexual arousal leads to the release of nitric oxide (NO) in the penile tissue. Nitric oxide stimulates the production of cyclic guanosine monophosphate (cGMP), a compound that relaxes smooth muscles and increases blood flow. PDE5 breaks down cGMP, leading to the cessation of an erection. By inhibiting PDE5, Malegra-120 allows cGMP to accumulate and persist longer, resulting in improved blood flow and a sustained erection.
Indications and Usage
Malegra-120 is primarily indicated for the treatment of erectile dysfunction. It is intended for men who experience difficulty in achieving or maintaining an erection sufficient for satisfactory sexual performance. This medication is particularly suitable for those who have not found lower doses of Sildenafil effective.
Dosage and Administration
- Recommended Dose: The recommended starting dose of Malegra-120 is one tablet (120 mg) taken orally with water, approximately 30 to 60 minutes before sexual activity.
- Administration: The tablet should be swallowed whole, without crushing or chewing, to ensure proper absorption.
- Timing: It is best to take Malegra-120 on an empty stomach for quicker onset of action. However, it can also be taken with food, though high-fat meals may delay its effectiveness.
- Frequency: Do not take more than one tablet within a 24-hour period. Adjustments in dosage should only be made under medical supervision.
Potential Side Effects
While Malegra-120 is generally well-tolerated, some individuals may experience side effects. These can range from mild to severe and should be monitored closely.
- Common Side Effects:
- Headache
- Flushing
- Dizziness
- Indigestion
- Nasal congestion
- Visual disturbances (e.g., blurred vision, changes in color vision)
- Serious Side Effects:
- Priapism (prolonged and painful erection lasting more than 4 hours)
- Severe hypotension (low blood pressure)
- Sudden hearing loss
- Myocardial infarction (heart attack)
- Stroke
If any severe side effects occur, discontinue use immediately and seek medical attention.
Precautions and Warnings
Before using Malegra-120, consider the following precautions and warnings:
- Medical Conditions: Inform your healthcare provider if you have any underlying medical conditions such as heart disease, high or low blood pressure, liver or kidney disease, a history of stroke, or any other significant health issues.
- Drug Interactions: Malegra-120 can interact with other medications, particularly nitrates used for chest pain, alpha-blockers for hypertension, and other PDE5 inhibitors. These interactions can lead to dangerous drops in blood pressure or other adverse effects.
- Allergies: Ensure you are not allergic to Sildenafil Citrate or any other ingredients in Malegra-120.
- Alcohol: Limit or avoid alcohol consumption when taking this medication, as it can increase the risk of side effects and reduce its effectiveness.
- Grapefruit: Avoid grapefruit and grapefruit juice as they can interfere with the metabolism of Sildenafil, leading to increased risk of side effects.
Contraindications
Malegra-120 should not be used in the following scenarios:
- Nitrate Therapy: Concurrent use with nitrates (e.g., nitroglycerin) or nitric oxide donors.
- Severe Cardiovascular Disorders: Patients with severe heart conditions or who are advised against sexual activity due to health reasons.
- Known Hypersensitivity: Individuals with a known allergy to Sildenafil Citrate or any component of Malegra-120.
Storage
Store Malegra-120 tablets at room temperature (between 20-25°C or 68-77°F), away from moisture, heat, and direct sunlight. Keep out of reach of children and pets.
Conclusion
Malegra-120 is a highly effective treatment for erectile dysfunction, offering a higher dose option for those who require it. Manufactured by Sunrise Remedies, this medication leverages the proven efficacy of Sildenafil Citrate to provide improved erectile function and sexual satisfaction. As with any medication, it is essential to use Malegra-120 under the guidance of a healthcare provider, adhering to recommended dosages and considering potential interactions and side effects. With proper use, Malegra-120 can significantly enhance the quality of life for men experiencing erectile dysfunction.
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