Buy Livmarli (maralixibat) Online

Livmarli (maralixibat) is a prescription medication that belongs to the drug class of bile acid transporter inhibitors. It is used to treat cholestatic pruritus (itch) in patients with Alagille syndrome who are at least 1 year old.

Mechanism of Action

Maralixibat works by blocking the ileal bile acid transporter (IBAT). IBAT is responsible for reabsorbing bile acids from the gut. By blocking IBAT, maralixibat increases the amount of bile acids that are excreted in the feces. This can help to reduce the levels of bile acids in the blood and relieve the itching associated with Alagille syndrome.

Dosage and Administration

Livmarli is taken once daily by mouth. The recommended dosage is based on the patient’s weight. The starting dosage is 1 mg/kg for patients who weigh less than 12 kg and 2 mg/kg for patients who weigh 12 kg or more. The dosage may be increased or decreased depending on how well the patient tolerates the medication and how well it is working.

Effectiveness

In clinical trials, Livmarli has been shown to be effective in reducing cholestatic pruritus in patients with Alagille syndrome. In one study, Livmarli reduced the severity of pruritus by at least 50% in 74% of patients after 12 weeks of treatment.

Side Effects

The most common side effects of Livmarli are:

• Diarrhea
• Abdominal pain
• Nausea
• Vomiting
• Decreased appetite
• Fatigue
• Headache
• Rash

Livmarli can also cause serious side effects, such as:

• Severe diarrhea
• Dehydration
• Liver problems
• Kidney problems
• Vitamin deficiencies

Contraindications

Livmarli is not safe for everyone. Tell your doctor if you are pregnant or breastfeeding, or if you have any other medical conditions, including:

• Liver disease
• Kidney disease
• Intestinal obstruction
• Short bowel syndrome
• Cystic fibrosis

Livmarli may also interact with other medications you are taking. Tell your doctor about all the medications you are taking, including prescription drugs, over-the-counter drugs, vitamins, and herbal supplements.

Conclusion

Livmarli is an effective treatment for cholestatic pruritus in patients with Alagille syndrome. However, it is important to be aware of the potential side effects of Livmarli before starting treatment. Talk to your doctor about the risks and benefits of Livmarli to determine if it is right for you.