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Buy LEVOTIRON 50mcg Tablets (Levothyroxine Sodium) Online

CHARACTERISTICS
ACTIVE SUBSTANCE LEVOTHYROXINE SODIUM
FORM 100 PILLS X 50 MCG
MANUFACTURER ABDI IBRAHIM

$10.45

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SKU:571236

1. Introduction

Levotiron 50mcg Tablet is a pharmaceutical product manufactured by Abdi İbrahim, a leading company in the pharmaceutical industry. This medication contains Levothyroxine Sodium as the active ingredient, which is a synthetic form of the naturally occurring thyroid hormone, thyroxine (T4). Levotiron is commonly prescribed for patients with thyroid hormone deficiency, known as hypothyroidism, and other related thyroid disorders. Each tablet contains 50 micrograms (mcg) of Levothyroxine Sodium and is packaged in a blister pack containing 100 tablets.

2. Indications

Levotiron 50mcg is indicated for the treatment of:

  • Hypothyroidism: A condition where the thyroid gland does not produce enough thyroid hormones. Levothyroxine Sodium supplements the deficiency, restoring normal metabolic functions.
  • Goiter: Used to reduce the size of thyroid nodules and prevent the recurrence of goiter after surgery.
  • Thyroid Cancer: As part of the treatment regimen to suppress thyroid-stimulating hormone (TSH) in patients with certain types of thyroid cancer.
  • Pituitary TSH Suppression: Levotiron can be used in diagnostic tests for the suppression of TSH.

3. Mechanism of Action

Levothyroxine Sodium is a synthetic form of the thyroid hormone thyroxine (T4), which is naturally produced by the thyroid gland. Upon ingestion, Levothyroxine Sodium is absorbed into the bloodstream and converted into triiodothyronine (T3), the active form of thyroid hormone, within the body. T3 binds to thyroid hormone receptors in various tissues, regulating gene expression and maintaining the normal metabolic rate, energy levels, and overall homeostasis.

4. Dosage and Administration

Standard Dosage:

  • The starting dose for adults typically ranges from 25 to 50 mcg per day, depending on the patient’s age, weight, cardiac status, and severity of hypothyroidism.
  • The dosage is adjusted based on the patient’s response and thyroid function tests. In most cases, the dose is increased gradually by 25 to 50 mcg every 4 to 6 weeks until the desired TSH level is achieved.
  • For children and elderly patients, the dosage is generally lower and adjusted more cautiously.

Administration:

  • Levotiron 50mcg Tablet should be taken orally, preferably on an empty stomach, 30 to 60 minutes before breakfast, to enhance absorption.
  • The tablet should be taken with a full glass of water and should not be chewed or crushed.
  • Consistency in the timing of administration is crucial for maintaining stable thyroid hormone levels.

5. Pharmacokinetics

Absorption:
Levothyroxine is well absorbed from the gastrointestinal tract, with an absorption rate of approximately 40-80%. The absorption is higher when taken on an empty stomach and can be influenced by various factors, including the presence of certain foods and medications.

Distribution:
Once absorbed, Levothyroxine is distributed widely throughout the body, with a large portion bound to plasma proteins such as thyroxine-binding globulin (TBG), transthyretin, and albumin. The unbound portion is the biologically active form.

Metabolism:
Levothyroxine is primarily converted to T3 in the liver and kidneys. The T4 to T3 conversion is a crucial step in maintaining the physiological activity of thyroid hormones.

Excretion:
The drug is excreted mainly through the kidneys, with a half-life of about 7 days in euthyroid patients. In hypothyroid patients, the half-life is prolonged, while in hyperthyroid patients, it is shortened.

6. Contraindications

Levotiron 50mcg Tablet is contraindicated in patients with:

  • Untreated Thyrotoxicosis: Levothyroxine should not be used in patients with hyperthyroidism or thyrotoxicosis as it can exacerbate the condition.
  • Uncorrected Adrenal Insufficiency: The use of Levothyroxine in patients with uncorrected adrenal insufficiency can precipitate an adrenal crisis.
  • Acute Myocardial Infarction: Caution is advised in patients with recent or ongoing myocardial infarction due to the potential for increased cardiac workload.
  • Hypersensitivity to Levothyroxine: Patients with known hypersensitivity to Levothyroxine Sodium or any of the excipients should avoid this medication.

7. Warnings and Precautions

  • Cardiovascular Risk: Patients with cardiovascular disease should be monitored closely as Levothyroxine can increase heart rate and myocardial oxygen demand, potentially leading to arrhythmias or exacerbation of angina pectoris.
  • Bone Mineral Density: Long-term use of Levothyroxine, particularly in high doses, can decrease bone mineral density, increasing the risk of osteoporosis, especially in postmenopausal women.
  • Diabetes Mellitus: Levothyroxine can affect glycemic control. Diabetic patients may require adjustments to their antidiabetic medication.
  • Pregnancy and Lactation: Levothyroxine is considered safe for use during pregnancy and lactation. The dosage may need adjustment during pregnancy to maintain appropriate thyroid hormone levels.
  • Interactions with Other Medications: Levothyroxine can interact with several medications, including anticoagulants, insulin, oral hypoglycemic agents, and certain antidepressants. It’s important to consult with a healthcare provider before starting or stopping any medication.

8. Side Effects

While Levotiron 50mcg is generally well-tolerated, some patients may experience side effects, particularly if the dosage is too high. Common side effects include:

  • Palpitations
  • Tachycardia
  • Increased Sweating
  • Weight Loss
  • Insomnia
  • Tremors

In rare cases, patients may experience more severe side effects such as:

  • Cardiac Arrhythmias
  • Heart Failure
  • Angina Pectoris
  • Hyperthyroidism (due to overdosage)

Patients are advised to seek medical attention if they experience any unusual symptoms or side effects.

9. Drug Interactions

Levotiron 50mcg Tablet may interact with a variety of medications, including but not limited to:

  • Cholestyramine and Colestipol: These medications can reduce the absorption of Levothyroxine, leading to decreased efficacy.
  • Calcium and Iron Supplements: These supplements should be taken at least 4 hours apart from Levotiron as they can interfere with its absorption.
  • Antacids: Some antacids containing aluminum hydroxide can reduce the absorption of Levothyroxine.
  • Warfarin: Levothyroxine can enhance the anticoagulant effects of warfarin, necessitating more frequent monitoring of INR levels.

10. Overdose and Management

An overdose of Levotiron 50mcg can result in symptoms of hyperthyroidism, including increased heart rate, anxiety, tremors, and insomnia. In severe cases, it can lead to a thyroid storm, which is a life-threatening condition.

Management of Overdose:

  • Immediate medical attention is required.
  • Treatment is largely supportive and symptomatic.
  • Beta-blockers may be administered to control symptoms such as tachycardia and anxiety.
  • Activated charcoal may be used in recent ingestions to limit absorption.
  • Monitoring of thyroid function tests and cardiac status is essential.

11. Storage and Handling

  • Storage Conditions: Levotiron 50mcg Tablets should be stored at room temperature, between 15°C and 25°C (59°F and 77°F), in a dry place away from light and moisture.
  • Shelf Life: The product should be used before the expiration date indicated on the packaging.
  • Handling Precautions: The tablets should be kept in their original packaging until ready for use to protect them from moisture and light. They should be kept out of reach of children.

12. Patient Counseling Information

Patients prescribed Levotiron 50mcg should be informed about the importance of taking the medication consistently as directed, without skipping doses. They should be educated on the potential side effects and the need for regular monitoring of thyroid function to ensure the dosage is appropriate.

Patients should also be advised to inform their healthcare provider about any other medications they are taking, including over-the-counter drugs and supplements, to avoid potential interactions.

13. Conclusion

Levotiron 50mcg Tablet, manufactured by Abdi İbrahim, is an essential medication for the management of hypothyroidism and related thyroid disorders. With its active ingredient, Levothyroxine Sodium, it plays a crucial role in restoring normal thyroid function and maintaining overall metabolic balance. Proper dosage, regular monitoring, and patient adherence are key to the successful management of thyroid conditions with Levotiron.

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