Enbrel Pre-Filled Pen is a biologic medication containing the active substance etanercept. It is used primarily to treat various autoimmune diseases by inhibiting the tumor necrosis factor (TNF), a protein that plays a significant role in inflammatory processes.
Each Enbrel Pre-Filled Pen contains:
- Etanercept 50 mg: A recombinant DNA-derived protein that inhibits TNF, which helps in reducing inflammation and immune response.
Indications:
Enbrel is indicated for the treatment of:
- Rheumatoid Arthritis (RA): For moderate to severe active RA in adults. It can be used alone or in combination with methotrexate.
- Psoriatic Arthritis (PsA): For active and progressive PsA in adults.
- Ankylosing Spondylitis (AS): For active AS in adults.
- Plaque Psoriasis: For chronic moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.
- Juvenile Idiopathic Arthritis (JIA): For moderate to severe active polyarticular JIA in children aged 2 years and older.
Mechanism of Action:
Etanercept is a TNF blocker that binds to TNF molecules in the body, preventing them from interacting with cell surface receptors. This helps in reducing the inflammatory response that contributes to autoimmune diseases, thereby alleviating symptoms and preventing further joint damage.
Administration:
- Dosage: The recommended dose for adults is 50 mg per week, administered as a single subcutaneous injection.
- Form: Each pre-filled pen contains a single dose of 50 mg etanercept.
- Method: The pen is designed for easy, self-administered injections under the skin. Detailed instructions are provided in the package insert to ensure proper use.
Features and Benefits:
- Convenience: The pre-filled pen format allows for straightforward, once-weekly administration, enhancing patient adherence.
- Precision: Pre-measured doses ensure accurate delivery of medication.
- Ease of Use: Ergonomically designed pen for easy handling and reduced injection discomfort.
Storage:
- Store Enbrel pre-filled pens in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze.
- Keep the pens in the original carton to protect them from light.
Warnings and Precautions:
- Infections: Patients should be monitored for infections before, during, and after treatment. Enbrel may increase the risk of serious infections.
- Allergic Reactions: Serious allergic reactions, including anaphylaxis, can occur.
- Malignancies: There is a risk of malignancies, including lymphoma.
- Heart Failure: Use with caution in patients with heart failure.
- Autoimmune Reactions: Autoimmune antibodies may develop, leading to potential autoimmunity-related adverse effects.
Side Effects:
Common side effects include injection site reactions, infections, headache, and rash. Serious side effects can include severe infections, neurological events, and blood disorders.
Manufacturer Information:
- Company: Pfizer Inc.
- Contact: Pfizer’s customer service and medical information departments are available for any inquiries or further information regarding Enbrel.
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