Chemical name: (6R-trans)-6-(1,3-benzodioxol-5-yl)- 2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1′, 2′
Formula: C22H19N3O4
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
ELI-20
Overview
Eli-20 (Generic Cialis, Tadalafil) is a medication containing Tadalafil as its active ingredient, manufactured by Alkem Laboratories. It is primarily used for the treatment of erectile dysfunction (ED) in adult males. Each pack of ELI-20 contains 10 pills, with each pill containing 20 mg of Tadalafil.
Active Ingredient
Tadalafil belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. This helps men to achieve and maintain an erection.
Mechanism of Action
Tadalafil, the active ingredient in ELI-20, works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). During sexual stimulation, nitric oxide is released into the erectile tissue of the penis, which activates the enzyme guanylate cyclase. This enzyme increases levels of cyclic guanosine monophosphate (cGMP), which relaxes the blood vessels in the penis and allows blood to fill the spongy erectile tissues to cause an erection.
Indications
ELI-20 is indicated for the treatment of erectile dysfunction (ED) in adult males. It is effective in improving erectile function and enabling satisfactory sexual intercourse. Tadalafil does not cure ED, but it helps manage symptoms of the condition.
Dosage and Administration
The recommended starting dose of ELI-20 is one 20 mg tablet taken orally, with water, approximately 30 minutes to 1 hour before sexual activity. The tablet can be taken with or without food. The maximum recommended dosing frequency is once per day.
For patients who anticipate frequent use of Tadalafil (at least twice weekly), a lower dose of 5 mg once daily may be considered based on individual tolerability.
Side Effects
Common side effects of ELI-20 may include:
- Headache
- Flushing
- Dyspepsia (indigestion)
- Back pain
- Nasal congestion
- Muscle aches
These side effects are usually mild to moderate and temporary. However, if they persist or worsen, patients should consult a healthcare professional.
Precautions and Warnings
Before using ELI-20, patients should inform their healthcare provider about any medical conditions they have, especially:
- Cardiovascular disease
- Kidney or liver problems
- History of stroke or heart attack
- Low blood pressure or uncontrolled high blood pressure
- History of vision problems, including retinitis pigmentosa
ELI-20 should not be taken with nitrates or nitric oxide donors, as this can cause a sudden drop in blood pressure. It should also be used with caution in patients taking alpha-blockers for the treatment of high blood pressure or prostate conditions.
Interactions
Tadalafil may interact with other medications, altering their effects or increasing the risk of side effects. Patients should inform their healthcare provider about all medications they are taking, including prescription and over-the-counter medicines, as well as herbal supplements.
Notable drug interactions include:
- Nitrates (e.g., nitroglycerin, isosorbide mononitrate)
- Alpha-blockers (e.g., doxazosin, tamsulosin)
- Antifungal medications (e.g., ketoconazole, itraconazole)
- HIV protease inhibitors (e.g., ritonavir, saquinavir)
- Antibiotics (e.g., erythromycin, clarithromycin)
Contraindications
ELI-20 is contraindicated in patients with a known hypersensitivity to Tadalafil or any inactive ingredients in the formulation. It should not be used in patients who are using nitrates or nitric oxide donors, as this combination can lead to a severe drop in blood pressure.
Storage
ELI-20 should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets. Do not use ELI-20 after the expiration date printed on the packaging.
Manufacturer
ELI-20 is manufactured by Alkem Laboratories, a leading Indian pharmaceutical company known for its commitment to quality and innovation in healthcare. Alkem Laboratories adheres to stringent manufacturing standards to ensure the safety, efficacy, and reliability of its products.
Conclusion
ELI-20 (Tadalafil Tablets 20 mg) is an effective treatment for erectile dysfunction in adult males. By increasing blood flow to the penis during sexual stimulation, Tadalafil helps men achieve and maintain an erection suitable for sexual activity. It is important for patients to follow the prescribed dosage and consult a healthcare provider if they have any concerns or experience side effects. With proper use, ELI-20 can improve the quality of life and restore confidence in men affected by erectile dysfunction.
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