Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
CAVERTA 100
Overview
CAVERTA 100, manufactured by Ranbaxy, is a highly effective medication used to treat erectile dysfunction (ED) in men. The active ingredient, Sildenafil Citrate, is a well-known phosphodiesterase type 5 (PDE5) inhibitor that helps men achieve and maintain an erection suitable for sexual activity. Each pack contains four tablets, each with a strength of 100 mg.
Mechanism of Action
Sildenafil Citrate works by enhancing the effects of nitric oxide, a natural chemical that the body produces to relax muscles in the penis. This relaxation of muscles allows for increased blood flow into the penile region upon sexual stimulation, leading to an erection. The drug specifically targets the PDE5 enzyme, which regulates blood flow in the penis. By inhibiting PDE5, Sildenafil Citrate ensures that blood vessels remain dilated and engorged with blood, facilitating a sustained erection.
Indications
CAVERTA 100 is primarily indicated for:
- Erectile Dysfunction (ED)
- Pulmonary Arterial Hypertension (PAH) in certain formulations (though not in the 100 mg dose typically)
Dosage and Administration
- Recommended Dose: The recommended dose is one 100 mg tablet taken as needed approximately 30 to 60 minutes before sexual activity.
- Maximum Dose: Do not exceed one tablet per day.
- Method of Administration: Swallow the tablet whole with water. It can be taken with or without food, but taking it with a high-fat meal may delay its onset of action.
Onset and Duration of Action
- Onset: Effects can be noticed within 30 to 60 minutes.
- Duration: The effects can last up to 4 hours, though this can vary from person to person.
Side Effects
Common side effects include:
- Headache
- Flushing
- Dyspepsia (indigestion)
- Nasal congestion
- Dizziness
- Visual disturbances (e.g., blurred vision, color tinge)
Less common but more serious side effects:
- Priapism (prolonged and painful erection)
- Sudden vision loss in one or both eyes
- Sudden hearing decrease or hearing loss
- Chest pain or irregular heartbeat
- Shortness of breath
If any of these severe side effects occur, seek immediate medical attention.
Precautions and Warnings
- Allergies: Do not use if you are allergic to Sildenafil or any other components of the tablet.
- Heart Problems: Patients with cardiovascular conditions should use CAVERTA 100 with caution. Consult with a healthcare provider if you have a history of heart disease, stroke, or arrhythmias.
- Interaction with Nitrates: Concurrent use with nitrates (often prescribed for chest pain) can cause a severe drop in blood pressure.
- Liver or Kidney Impairment: Dose adjustment may be necessary for patients with liver or kidney problems.
- Deformed Penis: Men with anatomical deformation of the penis (such as Peyronie’s disease) should consult their doctor before using CAVERTA 100.
- Retinitis Pigmentosa: Those with this rare inherited eye condition should avoid this medication.
Drug Interactions
CAVERTA 100 can interact with other medications, leading to potentially serious side effects. Key interactions include:
- Nitrates: Increased risk of hypotension.
- Alpha-Blockers: Can cause symptomatic hypotension.
- Other PDE5 Inhibitors: Avoid combination to prevent overdose.
- Protease Inhibitors: Used in HIV treatment, they can increase Sildenafil levels, requiring dose adjustment.
- Antifungals and Antibiotics: Certain drugs like ketoconazole and erythromycin can increase Sildenafil blood levels.
Use in Specific Populations
- Pregnancy and Breastfeeding: Not indicated for use in women.
- Geriatric Use: Older adults may require dose adjustments due to decreased liver and kidney function.
- Pediatric Use: Not indicated for use in individuals under 18 years of age.
Storage
- Temperature: Store at room temperature between 15-30°C (59-86°F).
- Moisture: Keep away from moisture and light.
- Child Safety: Keep out of reach of children.
Overdose Management
In case of overdose, seek emergency medical help. Symptoms of overdose may include severe dizziness, fainting, painful/prolonged erection, and chest pain. There is no specific antidote for Sildenafil overdose, and symptomatic and supportive treatment is recommended.
Patient Information
Before using CAVERTA 100, discuss your medical history with your healthcare provider, including any pre-existing conditions and any other medications you are taking. Follow the prescribed dosage and administration guidelines carefully to maximize benefits and minimize potential risks.
Conclusion
CAVERTA 100 by Ranbaxy is a trusted and effective solution for men suffering from erectile dysfunction. By enhancing blood flow to the penis, it helps men achieve and maintain an erection, thus improving sexual performance and overall quality of life. Always use this medication under the guidance of a healthcare professional to ensure safety and efficacy.
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