Chemical name: 2,2′-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
Formula: C17H19N5
Product Overview: ARIMIDEX 1mg (Anastrozole) by AstraZeneca is a potent, selective aromatase inhibitor indicated for the treatment of breast cancer in postmenopausal women. Packaged in a convenient form of 28 tablets, each containing 1mg of Anastrozole, this medication is designed to significantly reduce estrogen levels in the body, thereby slowing or halting the growth of hormone receptor-positive breast cancer.
Product Details:
- Active Ingredient: Anastrozole 1mg
- Manufacturer: AstraZeneca
- Formulation: Film-coated tablets
- Pack Size: 28 tablets per pack
Indications:
- Primary Use: Treatment of hormone receptor-positive breast cancer in postmenopausal women.
- Other Uses: May also be used as an adjuvant treatment for early-stage breast cancer or as a first-line treatment for advanced or metastatic breast cancer.
Mechanism of Action: Anastrozole works by inhibiting the aromatase enzyme, which is responsible for the conversion of androgens into estrogens. By blocking this enzyme, Anastrozole significantly lowers estrogen levels in the body. Estrogen is a hormone that can promote the growth of certain types of breast cancer cells. Reducing estrogen levels helps to slow down or stop the growth of these cancer cells.
Dosage and Administration:
- Recommended Dose: One 1mg tablet taken once daily.
- Administration: Can be taken with or without food. It is important to take the medication at the same time each day for optimal effectiveness.
- Duration: The length of treatment varies depending on the individual’s condition and response to therapy. Always follow the prescribing physician’s guidelines.
Contraindications:
- Pre-Menopausal Women: Not recommended for use in women who have not yet gone through menopause.
- Pregnancy and Breastfeeding: Not suitable for use during pregnancy and breastfeeding due to potential harm to the fetus or nursing infant.
- Hypersensitivity: Patients with known hypersensitivity to Anastrozole or any of the excipients in the formulation should avoid use.
Side Effects: Common side effects may include:
- Hot flashes
- Joint pain or stiffness
- Weakness
- Sore throat
- High blood pressure
- Nausea and vomiting
- Rash
Serious side effects requiring immediate medical attention include:
- Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, trouble breathing)
- Bone fractures
- Liver problems (e.g., yellowing of the skin or eyes, dark urine, persistent nausea/vomiting)
- Chest pain
Storage:
- Store in a cool, dry place at room temperature (below 30°C).
- Keep out of reach of children.
- Store in the original packaging to protect from moisture and light.
Additional Information: Regular monitoring of cholesterol levels, liver function, and bone mineral density is recommended during treatment. Patients should inform their healthcare provider of any other medications they are taking, as drug interactions may occur.
Summary: ARIMIDEX 1mg (Anastrozole) by AstraZeneca is an essential medication for the management of hormone receptor-positive breast cancer in postmenopausal women. With its proven efficacy in reducing estrogen levels, it offers a critical option for slowing or halting the progression of breast cancer, thereby improving patient outcomes.
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