German Skin aging Biotechnology Laboratory research found that Solidago Virgaurea subSP extract from Canadian Solidago Virgaurea (hereinafter referred to as SVS) can go deep into the skin to poison pro-aging cells, block the vicious cycle of inducing skin aging, restore skin vitality, and achieve the effect of pit aging. The findings are published in the Cooperative Nature Journal.

Canadian goldenrod

Introduction to the

Solidago virgaurea, traditionally used as an anti-inflammatory herb. The compounds isolated have been reported to have cytotoxic, antimicrobial, anti-mutagenic, antifungal, analgesic, anti-inflammatory, antioxidant and diuretic activities. However, SVS has not been previously studied in cell senescence.

Prospective studies on the root causes of senescence have shown that senescent cells accumulate in the body with aging, and their secretion of pro-inflammatory factors and chemokines induce chronic and persistent aging of surrounding tissues, and fall into a vicious cycle.

The organ in which senescent cells are most commonly found is the skin, where the dermis contains 20-60% senescent fibroblasts. They produce ECM and growth factors that have a lasting effect on the epidermis.

This has led to the hypothesis that human skin aging may involve a process in which the dermis continuously releases signals inducing epidermal aging. That is, the new cells lose their unique structure and function after induction and turn into useless cells, and are further induced to change into senescent cells, this process is called transdifferentiation to redifferentiation transition (PRT).

This study confirmed and reported that solidago officinarum extract can block the persistent negative effects of senescence in human dermal cells, including SASP and PRT, in vitro.

Studies have shown that long-term treatment with SVS delayed senescence and PRT of human dermal cells

To identify plant extracts that affect PRT activity, seven different plant extracts were screened, with the selection criteria focusing on the ability to induce cellular characteristics of papillary human dermal fibroblasts (HDF) and reduce SA-β -galactosidase activity.

SVS showed the most significant effect in changing cell morphology and reducing SA-β -galactosidase activity, and was selected for further study.

To investigate the effects of long-term exposure to SVS, HDF was cultured from population multiplication in the presence of SVS.

Cells in the SVS group maintained healthy cell numbers for up to 160 days, compared with just 95 days in the control group.

“SVS has no effect on normal cell growth and metabolic cycle, but preserves the youthful morphology of cells,” the researchers found.

Therefore, the laboratory concluded that :(I) consistent with the results of previous studies, SVS have the ability to delay senescence, PRT reproductively induces cell senescence, resulting in a reticular state of senescent fibroblasts, and (ii) PRT senescence is delayed by SVS treatment.

SVS reduced the appearance of senescence but did not affect the healthy cell growth cycle

To investigate the effect of SVS on already senescent cells, HDF was treated with SVS after SIPS was induced with chronic oxidative stress and compared with fused stationary cells.

The number of SA-β -Gal positive SIPS cells had been significantly reduced after 4 and 11 days of treatment, suggesting that SVS did also affect cells that were completely senescent before treatment, without affecting the growth cycle of healthy cells.

SVS showed high anti-aging activity

To evaluate the anti-aging ability of SVS, SIPS and quiescent HDF were cultured with SVS for 39 days.

Treatment with SVS resulted in a significant 30% reduction in the number of senescent cells, while the number of stationary cells was not significantly affected.

Short-term treatment with high dose suggested that the senescence principle of SVS is based on the induction of senescent cells apoptosis.

conclusion

SVS of solidago officinalis extract not only delayed the appearance of aging, but also did not affect the function of healthy cell cycle metabolism. SVS freezes the genes of senescent cells and reduces the secretion of various pro-senescence factors. Thus, the vicious cycle of rapid aging of new cells is improved.”

According to the team, the extract has been used in beauty and skin care, but only a small amount is available to skin management centers due to the difficulty of extracting and growing the extract. The team adds that intervention can only be done wisely if we understand the true causes of aging.