Category: Antiviral

Danilo Turk, former President of Slovenia and chairman of the World Leaders' League, said on Thursday that international cooperation is the most important factor in the global economic recovery and it is of great significance to make vaccines a global public good.

On the same day, While attending the Global Think tank Cloud Forum on CoVID-19 Cooperation, Turk said that the "shock" of coVID-19 has swept the world and many countries, including China, have made heroic efforts to defeat the epidemic.
Entering a new stage of development, mankind has undertaken major missions in various fields, including medical treatment and economy.

Turk noted that the recent World Health Assembly established a very comprehensive plan for combating the epidemic, which includes a lot of international cooperation.
"Addressing many of the current and potential challenges takes place simultaneously in the context of international cooperation and competition, where better management, particularly in vaccines, is critical."
He says there may be a lot of competition between different research institutions and different countries, and there is a great need for collaboration.

"We need to think about the global availability of vaccines, and in that sense it makes a lot of sense for vaccines to be a global public good."
"That means we need to make vaccines globally accessible, affordable for governments in low - and middle-income countries," Turk said.

In addition, Turk said new features are emerging throughout the epidemic, such as how to ensure global supply chains.
"It's not just an economic issue, it's a process of action, and it requires some policy, decision support."

To achieve this, Turk said, "low - and middle-income countries need policy assistance, and institutions like the IMF can be involved, and we need that cooperation."

In Turk's view, every country may encounter a common situation, which is the problem of employment.
"It is a priority to ensure that the world does not slide into a serious crisis."
Turk said that the employment problem has been very serious in some countries, but China has made very positive progress in solving the employment problem.

"We are seeing developments on the domestic demand side in China and some of the demand is coming from smes.
Most of this is driven by domestic demand."
Turk noted that many countries around the world need to understand the details of China's current economic recovery.
"China has made a commitment to quality development as the main direction for the future, including the development of the entire healthcare system."

"This is a difficult time for the world, but it is also a time of great opportunity."
"We want to do our best to build a more resilient, people-centric economy," Mr. Turk said.

At a regular briefing on COVID-19, WHO Director-General Tedros Adhanom Ghebrev said the public should be encouraged to wear face masks when the epidemic is widespread and it is difficult to maintain physical distance.

According to the Chinese embassy posted on June 3, the evening of June 1 2020, ambassador liu xiaoming attended the British sky news special programs after the outbreak of our new online interview, and former Irish President Mary Robinson, a former British foreign secretary David miliband, the American historian niall ferguson, a global influence, China's resistance to disease of epidemic, the outbreak of independent investigation, such as climate change, the situation in Hong Kong to discuss, online and answer questions from the audience.
The talk show is hosted by Sky's famous presenter, Monahan.
The TV, website, new media platform for live broadcast.
The transcript of Ambassador Liu's questions and answers is as follows:

Monahan: First of all, would you please talk about the opportunities and challenges facing our world?

Ambassador Liu: What will be the impact of the epidemic?
Will the world unite, or become more divided?
There is a lot of discussion around this issue.
I think the epidemic will bring the world together.
The epidemic once again proves that mankind lives in a global village.
As President Xi Jinping said, we should strive to build a community with a Shared future for mankind.
In my view, the epidemic once again shows that the international community should strengthen cooperation.
Facts have shown that all countries that have joined hands to fight coVID-19, supported the WHO, listened to the WHO's recommendations and supported multilateralism are under effective control.
Countries that rejected international cooperation and who recommendations paid a heavy price.
The epidemic has proved that no country, no matter how strong it is, can be immune to the virus, because the virus knows no borders and no race.

Monahan: Speaking of international investigations, the central question is: is China responsible for the crisis?
Will independent investigators be allowed to enter Chinese territory to conduct field investigations?

Ambassador Liu: Of course we welcome the international review.
But the purpose of the review is not to label any country, but to cover all countries closely associated with the epidemic.
At the World Health Assembly, we joined with 120 WHO member states in supporting the international community's review of this outbreak at the appropriate time, with a view to building lessons learned to better respond to major communicable diseases in the future.
The deliberations must be independent, exclude political interference, be science-based and scientist-led.

Monahan: Who does China think should lead the investigation?

Ambassador Liu: It should be led by the World Health Organization.
All countries should participate, especially the major ones.
I disagree with what Ferguson has just said.
His criticism of China's slow response is untrue.
Much of what Mr. Ferguson said was wrong, including the fact that many flights from Wuhan continued to fly to other countries during the lockdown.
This is wrong.
All flights were grounded after Wuhan was closed on January 23.
No flights, no trains, no external traffic.
China was the first country to report the outbreak to WHO, the first to isolate the pathogen, and the first to share the full genetic sequence of the virus with WHO and other countries.
China has wasted no time in sharing information and prevention and control experience with other countries.

Monahan: Many Chinese flights have not been grounded since the closure of Wuhan, which has caused the epidemic to spread to many countries. Isn't that a serious problem?

Ambassador Liu: Your information is totally wrong.
Wuhan has been cut off from the outside world, with no flights at all.
I am sorry to hear much of Ferguson's cold war rhetoric here. I know Ferguson but I do not know why he is so interested in cold war with China.
China is not the Soviet Union.
As a historian, you should study Chinese history carefully.
China has compiled a list of 24 lies and facts about the epidemic. I can send it to you.
Who's appreciation of China's efforts should not undermine the role of WHO.
Who is a major international organization with 194 member states.

Monahan: Is China responsible for the epidemic?
For a long time, China denied the transmission of the virus from animals to people and from person to person. You did not tell the world the truth in time.

Ambassador Liu: I have made it clear to you that China notified the WHO as soon as possible without any delay.
Novel Coronavirus is a novel virus.
In the face of unknown new viruses, we must adopt a responsible attitude, which requires serious and responsible research by scientists.
China identified the virus 11 days after the first case was detected and immediately notified the WHO, while sharing information with relevant countries.
China has nothing to hide and nothing to delay.
China's anti-epidemic record is clear and clear, which can stand the test of time and history.
I would also like to point out that just because China was the first to report the outbreak does not mean that the virus originated in China.
The origin of the virus needs to be explored by scientists.
With the development of the situation, we have seen some reports that the United States, Italy and other countries have found earlier cases than China.
Therefore, we should adopt a scientific attitude towards the problem of virus tracing.

Monahan: Will China agree to reform who?

Ambassador Liu: Of course.
The outbreak response reflects some of WHO's shortcomings, including inadequate response capacity and resources, how to respond faster and more effectively, and how to help the poorest and least able countries fight the epidemic.
Reform can come after we have overcome the epidemic.
As the epidemic continues to spread around the world, it is imperative to work in solidarity and support WHO in leading the fight against the epidemic.

Monahan: As the world's largest emitter, what steps will China take to maintain the current temporary reduction in emissions during the epidemic?

Ambassador Liu: China firmly supports the Paris Agreement and earnestly fulfills its obligations.
China has completed its carbon emission reduction plan three years ahead of schedule, and in 2018, its carbon emission intensity will be reduced by 45.8% over 2005.
China's energy consumption per unit of GDP fell 2.6 percent year on year in 2019.
China is the world's largest investor in new and renewable energy.
China is committed to tackling climate change.
China was scheduled to host the 15th Conference of the Parties to the Convention on Biological Diversity (COP15) before the end of this year.

Monahan: When does China plan to hold COP15?

Ambassador Liu: Because of the epidemic, the exact time has not been finalized.
This year was supposed to be a year of china-UK cooperation on environmental protection.
The UK has moved the 26th SESSION of the United Nations Climate Change Conference (COP26) to November next year, but we are still in close contact with our UK colleagues online to ensure the success of both conferences.

Monahan: I have a question about rebuilding trust and the novel Coronavirus vaccine competition.
We are seeing China and some countries leading the way in vaccine development.
If China develops an effective vaccine, will China be willing to share it with the world at the lowest possible price in order to rebuild trust?

Ambassador Liu: Of course.
At the World Health Assembly, President Xi Jinping solemnly declared that China's COVID-19 vaccine, when fully developed and put into use, will become a global public good, especially to make vaccines accessible and affordable to developing countries.
China is a world leader in vaccine research and development. Five of our vaccines have entered phase II clinical trials, and we are willing to share them with other countries.
China is also cooperating with scientists from Britain and the United States in research and development.

Just now, you showed a chart showing that the so-called "Reputation of China has been damaged". I do not agree with this conclusion.
It depends on where you get the information.
I can give you some information.
At the beginning of this year, The Trust Barometer, published by Edelman, the largest independent public relations company in the US, showed that 82 per cent of people in China trusted their government, the highest of any country surveyed.
In addition, according to a recent survey of 23 economies by Blackbox Research, a Singapore-based independent pollster, Chinese citizens' satisfaction with their government's response to the epidemic is the highest, with a combined score of 85%, ranking first again.

Monahan: We also want to hear from Ambassador Liu about the lack of trust in the government, especially among the younger generation.
This lack of trust can be seen on the streets of Hong Kong, "where the Chinese government cracks down on pro-democracy protesters".

Ambassador Liu: The situation in Hong Kong is far from the Chinese government cracking down on pro-democracy protesters. What is happening on the streets of Hong Kong is ongoing illegal violence.
These activities endanger China's national security.
Some violent activists stormed the Legislative Council of Hong Kong and even set fire to innocent people. If the same thing happened on the streets of London, if rioters stormed the British Parliament, how would the UK react?
Will the British government and police just sit back and let it happen?
I think any responsible government would take action.
On the other hand, one should not forget the great success of "one country, two systems" in Hong Kong since its return 23 years ago…
.

Monahan: Sorry, we're out of time.
I want to thank all the guests.
Thank you, Ambassador Liu.

In 1963, June Almeida was working at the Ontario cancer institute in Canada, where she was responsible for identifying and photographing virus particles using then-state-of-the-art electron microscopes.

The first person to identify a human coronavirus was a woman, June Almeida, a British virologist and expert in viral imaging.
She was born in Scotland, where her father was a bus driver, and began working as a migrant worker when she left school at the age of 16.

Later, almeida became a pioneer in the field of viral imaging.
That's why this long-forgotten name has been brought back to the world in the wake of covid-19.

Novel coronavirus is a novel strain of coronavirus that has never been found in humans before, belonging to the large family of coronaviruses.
The first human coronavirus was discovered under almeida's microscope in 1964.
She works in a laboratory at st Thomas's hospital in London.

The cold virus

Almeida was born in the northeast of Glasgow, Scotland, in 1930.
After graduating from junior high school she stopped formal schooling and took a job as a laboratory histopathological technician at Glasgow royal infirmary.

She moved to London from Scotland a few years later, married the Venezuelan artist Enriques Almeida in 1954, and soon after she had a daughter decided to move to Toronto, Canada.

As writer George Winters described, almeida mastered the art of electron microscopy at the Ontario cancer institute.

She also developed a way to image viruses using antibodies to make them polymerize.

Mr Winters told the BBC that Mr Almeida's talent was recognised by his British counterparts and he was "lured" back to work at st Thomas's hospital medical school in London in 1964.

Not to mention, Boris Johnson, the current prime minister of the UK, was treated and recovered from covid-19 in this hospital.

When almeida returned to Britain, he began working with Dr. David Tyrrell.
Dr Tyrol was running a cold virus laboratory in Salisbury, Wiltshire.

When Dr. Tirol and his team studied nasal fluid samples from volunteers, they found that a few, but not all, of the viruses associated with colds and colds could be grown in the lab.

One of the many samples, taken in 1960, came from a student at a boarding school in surrey, southern England, whose nose wash was labelled B814.

The team found that they were able to induce cold symptoms in volunteers, but were unable to do cell cultures with the virus. What was even more puzzling was that the cold virus was clearly visible in the tissues of the volunteers.

Dr Tyrol wondered if he could see the virus under an electron microscope.

They sent some samples to almeida's lab in London and asked her for help.
She saw virus particles under a microscope, a bit like a flu virus but not quite.

What she saw was actually the first human coronavirus.

Coronaviruses are a big family.
Microscopically, the virus shapes of this family have a common feature, that is, the lipid envelope is lined with widely spaced projections, whose shapes can be petal-shaped, conical, t-shaped and so on with different viruses.

Found rejected

Dr. Almeida had actually seen the particles before, winters said, when he was studying mouse hepatitis viruses and chicken bronchitis viruses.

However, the paper she submitted to a professional journal was rejected in the peer-review section, on the basis that the assessors considered the virus images she provided to be "nothing more than pictures of poorly formed influenza virus particles."

A paper based on virus particles found in the B814 sample was published in the British medical journal in 1965, and images of the virus particles she saw were published two years later in the journal of general virology.

Dr. Tyroll, Dr. Almeida and Dr. Tony Waterson, President of st. Thomas hospital, called the virus a coronavirus, according to Dr. Winters, because of the corona-like projections around the particles.

Ms. Almeida went on to continue her research at the Royal Postgraduate Medical School (now imperial college) in London, where she received her doctorate.

She ended her career at the wellcome institute in the United Kingdom, where she received several patents in the field of viral imaging.

After leaving the wellcome institute, almeida became a yoga instructor until the AIDS epidemic began in the 1980s, returning to her old career as a consultant involved in identifying and photographing HIV.

Joan almeida died in 2007 at the age of 77.

The Chinese New Year is supposed to be a time of reunion and celebration, but a covid-19 outbreak has disrupted people's normal pace of life.
Is this a good time to have a baby for couples who are trying to get pregnant during the extended holiday season?
The reporter of China women's news · China women's net interviewed professor bian wenhui, director of department of gynaecology of hebei hospital of traditional Chinese medicine at this point, she very affirmation answer: "not!"

Bian wen will say, now we have a strong sense of good birth and good breeding, as the saying goes, "can't let the child lose at the starting line", what is the starting line?
"The first three months of the union are the starting point for the future child."
As a fertilized egg evolves from a cell to a human being, the quality of the parents' sperm and eggs, the mother's physical condition, mental state and living environment after pregnancy will all influence the physical health of the future child, bian will explain.
Therefore, it is very important to choose an appropriate time to conceive.

What are some of the risk factors associated with covid-19?
Bian wenhui pointed out that, first of all, in the spiritual aspect, the epidemic is a big event for everyone, and many people are in a state of fear, nervousness and even confusion.
People stay at home, most of the people's work and rest is disorder, relaxation, life led to physical decline is inevitable.

In terms of diet, bian wen will point out that the long holiday home, almost every family is a big fish and big meat, eat sleep sleep.
Too much food is too thick be bored with adverse to the function of the spleen and stomach, the function of the spleen and stomach is bad, how can the body be good again?
On the other hand, fresh vegetables in winter are already relatively inadequate, and it is not convenient to go out to buy vegetables in unusual times, which leads to the lack of vegetables, incomplete diet and unavoidably nutritional imbalance.

As for environmental factors, the air quality in many places during the Spring Festival is poor and the smog is heavy. According to the meteorological department, the air pollution during this year's Spring Festival is particularly serious. "severe air pollution is by no means the best time to get pregnant," it said.
Side will say

What's more, it's not good to go to the hospital for an early checkup if you're pregnant now, bian said.
"At the moment of the epidemic, once you get pregnant, you have to go to the hospital for a regular pregnancy test, which is often the most dangerous place.
If you can't do the pregnancy test on time, it will lead to an increase in accidents.
If a pregnant woman becomes infected with covid-19, the consequences are even worse."

Bian wen will remind you that at present, I hope newlyweds can keep a happy mood, exercise their bodies and make adequate preparations before pregnancy. It is more appropriate to wait for the epidemic to pass and the warm spring flowers to bloom before giving birth to a new life.

In China, lung cancer has the highest morbidity and mortality, which can be said to be a kind of disease that seriously endangers people's health.Is lung cancer that difficult to cure?

There are a lot of patients with advanced non-small lung cancer abroad. Through CIMAvax vaccine inoculation, it is found that the tumor is getting smaller and smaller and the life is getting better and better.

What is the CIMAvax vaccine?

After more than a decade of development, Cuban molecular immunization experts finally developed the world's first therapeutic vaccine against non-small cell lung cancer, CIMAvax, in 1999.

Subsequently, CIMAvax lung cancer vaccine was launched in Cuba, venezuela, Peru, Paraguay, Colombia and other countries.In 2012, Cuba successfully developed a second lung cancer vaccine, Vaxira.This makes Cuba the only country in the world to have two lung cancer vaccines.

Clinically, the majority of lung cancer patients with lung cancer vaccine can achieve good results, more than half of the cases showed a reduction in tumor, and increased antibodies.

CIMAvax lung cancer vaccine, in fact, is not our traditional sense of the vaccine, it is a therapeutic vaccine, that is, for patients with confirmed lung cancer injection vaccination, can not prevent cancer, but can greatly extend the survival time of patients, improve the quality of life of patients.

What's so amazing about CIMAvax?

The growth of lung cancer cells depends on a substance called epidermal growth factor. CIMAvax is a vaccine made up of two proteins, epidermal growth factor and P64K.Once injected into the body, it stimulates the immune system of patients with non-small cell lung cancer to produce antibodies.Antibodies clear the body of epidermal growth factor (egf), causing lung cancer cells to lose nutrients and become "hungry", unable to proliferate and eventually die.

Normal cells also need epidermal growth factor for growth, but it's not the only one, so without this protein, normal cells can survive.So the vaccine has fewer side effects.

CIMAvax clinical

The 2008 CIMAvax study in the journal of clinical oncology included 80 patients with non-small cell lung cancer.The median survival time in the CIMAvax group was 11.6 months, compared with 5.3 months in the support group.In contrast, the CIMAvax group lived longer and had fewer side effects.

A multicenter, randomized Ⅲ period, 405 patients with clinical trials, all patients received platinum based chemotherapy (4 cycles) or less.Oxalibo (jiali) for injection is the third generation of platinum anticancer drug, which has better effect and fewer side effects than cisplatin and carboplatin.

405 patients were randomly assigned to receive the best supportive treatment or CimaVax vaccination.The experimental group (270 persons) received cyclophosphamide adjuvant therapy for 3 days after first-line chemotherapy, followed by immunotherapy once a month for 4 weeks.The control group (135) received optimal support therapy.The results showed that among the 405 patients with NSCLC, the median survival time was 12.4 months in the vaccine group and 9.4 months in the single supportive care group.

Treatment and precautions of CIMAvax

CIMAvax vaccine therapy for lung cancer is divided into two phases: induction phase and maintenance phase.

One course of treatment of CIMAvax vaccine for lung cancer is 10 vials of red and blue, equivalent to about 20,200 yuan.Two injections each time, one red and one blue vial each.The first four injections were given at 2 weeks, and the fifth injection was given one month after the last injection.That's 5 injections per course.

Patients who are allergic to CIMAvax should stop using it immediately.The most frequent adverse reactions that may occur are: local erythema or swelling;Body can appear blush, headache, chills, cramps, anorexia, nausea, fever, hot flashes, breathing difficulties.

Can CIMAvax only be used for lung cancer?

The role of epidermal growth factor receptor (EGFR) in lung cancer, especially non-small cell lung cancer, has been demonstrated.The CIMAvax vaccine, however, is not suitable for all people. It is effective only in patients with advanced non-small cell lung cancer, but not in patients with advanced lung cancer or brain metastases.

Egfr is also a target for cancers such as colorectal cancer, head and neck tumors, breast cancer, and thyroid cancer.If CIMAvax is improved in the future, it could be used to treat other cancers.

Is CIMAvax on the market in China?

There has been no follow-up to the phase 1 CimaVax trial conducted by the Chinese academy of medical sciences in 2013.But China has no trade restrictions.If non-small cell lung cancer patients in China want to be treated with the CIMAvax vaccine, they can go to Cuba to get it through the program.

Clinical trials of the CIMAvax vaccine were launched in the United States in 2018, but the clinical trials require extensive verification.Generally, it takes several years to get FDA approval before it can be marketed in the United States.

Overall, the CIMAvax vaccine has been used in many countries for many years as a new hope for the treatment of non-small cell lung cancer patients.Although lung cancer can not be completely cured, but can greatly prolong the survival of patients, into a chronic disease, some patients can even achieve clinical cure.This is the progress of medical technology!

Several countries around the world are focusing on novel coronavirus vaccines, a key to preventing future pandemics.The vaccine is not yet complete, but China electronics announced the completion of the world's largest novel coronavirus vaccine manufacturing plant with an annual capacity of up to 100 million doses.

China electronics co., LTD. (hereinafter referred to as CLP 4) announced the successful completion of the delivery of the first domestic P3 bio-pharmaceutical production workshop contracted by its subsidiary China electronic systems engineering fourth construction co., LTD. (hereinafter referred to as CLP 4), which is the world's largest novel coronavirus vaccine production workshop and can produce 100 million doses of vaccine per year after mass production.

According to the report, CLP four companies after the Spring Festival began to take on multiple domestic first whole virus inactivated seedlings high-level biosafety vaccine production workshop general contracting of construction, the construction of vaccine production workshop to fill the domestic blank of biological safety of the major disease prevention and control in the field of vaccine, 19 outbreak of COVID - drugs and vaccine research and development is of great significance.

In the novel coronavirus vaccine research and development, WHO announced that there are 8 vaccines entering the clinical trial phase, among which 4 are from Chinese companies, 3 are from the United States, and 1 is from the United Kingdom.Among the Chinese vaccines, sinovac's inactivated vaccine has released partial trial results, which show that the vaccine is safe and effective.

According to the website information, China electronic systems engineering fourth construction co., LTD. (CLP) four company was founded in 1953, belongs to CEC's China electronics technology co., LTD, is a focus on electronic information, biological, pharmaceutical, chemical, environmental protection, data center, in the field of automobile, new energy and other high-tech manufacturing engineering consulting, engineering design, engineering contracting, and facility management comprehensive engineering and technical services company.

A few days ago, Swedish environmental girl Greta Tengberg donated a total of US $ 100,000 from the Danish non-profit organization Human Action to UNICEF to protect children during the fight against the virus pandemic.

Comprehensive foreign media news, the Human Action Group dedicated to eliminating extreme poverty on a global scale awarded the money to Greta Tenberg, in recognition of her unremitting efforts in climate protection.

The organization also donated an additional US $ 100,000 for UNICEF activities to increase Temberg ’s donations. These funds will be used to provide food, health care, educational support and various other services as part of a wider UNICEF campaign to address the problems children face during the pandemic.

Greta Tenberg said in a statement, "Like the climate crisis, the coronavirus pandemic is a crisis of children ’s rights that will affect all children. Now and in the long run, vulnerable groups will be affected. The most serious impact. I ask everyone to stand up and join me in supporting the important work of UNICEF to save children ’s lives, protect health, and continue education. "

It is reported that through this campaign, UNICEF will also distribute basic hygiene products, including personal protective equipment and hygiene bags.

These efforts are part of the United Nations Global Humanitarian Response to Viruses, which seeks to raise $ 2 billion to control the virus and support affected communities.

The response plan includes a $ 350 million appeal for immediate logistics expansion so that United Nations agencies can distribute basic supplies around the world.

In particular, UNICEF provides school meals for children during school suspension, oversees a global learning platform, launches a campaign for a global ceasefire, and delivers medical supplies to low-income countries.

United Nations Children ’s Fund Executive Director Fore said, "This coronavirus pandemic is the worst fight in the world for generations. Children and young people are one of the people most affected by the 'COVID-19' chain effect , So it ’s natural for them to want to do something. "

Greta Tenberg said in a recent Earth Day video on YouTube, "Whether we like it or not, the world has changed, and the situation is completely different now than it was a few months ago. It may never be the same again. The same as before, we must choose a new way forward. "