Introduction
D-Force is a medication primarily used to treat premature ejaculation (PE) in men. It contains dapoxetine hydrochloride, a selective serotonin reuptake inhibitor (SSRI) that is specifically formulated to delay ejaculation and improve control over ejaculation time. Manufactured by Zenit Pharma, D-Force is designed to enhance sexual satisfaction and improve overall sexual health for men experiencing premature ejaculation.
Active Ingredient: Dapoxetine
Dapoxetine is the active pharmaceutical ingredient in D-Force. It works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a result, delaying ejaculation reflex and prolonging the time to ejaculation.
Indications
D-Force is indicated for the treatment of premature ejaculation (PE) in adult men aged 18 to 64 years. Premature ejaculation is defined as persistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the person wishes it. D-Force helps improve control over ejaculation and increase the time interval before ejaculation occurs during sexual intercourse.
Dosage and Administration
Dosage:
The recommended starting dose of D-Force is 30 mg, taken as needed approximately 1 to 3 hours before anticipated sexual activity. Based on efficacy and tolerability, the dose may be increased to a maximum of 60 mg. D-Force should not be taken more than once every 24 hours.
Administration:
D-Force tablets should be swallowed whole with a full glass of water. They can be taken with or without food. Alcohol consumption should be avoided or limited while taking D-Force, as it may increase the risk of adverse effects.
Mechanism of Action
Dapoxetine, the active ingredient in D-Force, is a selective serotonin reuptake inhibitor (SSRI). It inhibits the reuptake of serotonin by neurons, which increases the action of serotonin at the postsynaptic cleft and enhances neurotransmission. This mechanism of action helps to delay the reflex that causes ejaculation, thereby improving control over ejaculation and increasing intravaginal ejaculatory latency time (IELT).
Pharmacokinetics
Absorption:
Dapoxetine is rapidly absorbed after oral administration, with peak plasma concentrations occurring approximately 1 to 2 hours after dosing.
Distribution:
Dapoxetine is highly bound to plasma proteins (approximately 99%). It has a large volume of distribution, indicating extensive tissue distribution.
Metabolism:
Dapoxetine is extensively metabolized in the liver primarily via the CYP2D6 and CYP3A4 enzyme pathways. The major metabolites are pharmacologically inactive.
Elimination:
The half-life of dapoxetine is approximately 1 to 1.3 hours. It is primarily eliminated in the urine as metabolites.
Side Effects
Common side effects of D-Force may include:
- Nausea
- Headache
- Dizziness
- Diarrhea
- Insomnia
These side effects are generally mild to moderate in nature and often resolve with continued use. If any of these side effects persist or worsen, patients should consult a healthcare professional.
Contraindications
D-Force is contraindicated in patients with:
- Hypersensitivity to dapoxetine or any of the excipients in the tablet
- Moderate to severe hepatic impairment
- Severe renal impairment
- Concurrent use of monoamine oxidase inhibitors (MAOIs), thioridazine, serotonin-norepinephrine reuptake inhibitors (SNRIs), or other SSRIs
Drug Interactions
D-Force may interact with certain medications, including:
- MAOIs (e.g., phenelzine, tranylcypromine)
- SNRIs (e.g., venlafaxine, duloxetine)
- SSRIs (e.g., fluoxetine, sertraline)
- Thioridazine
- Linezolid
- Tramadol
- Tryptophan
Patients should inform their healthcare provider about all medications and supplements they are taking before starting treatment with D-Force to avoid potential interactions.
Precautions
Before taking D-Force, patients should inform their healthcare provider if they have any underlying medical conditions, including:
- History of orthostatic hypotension
- Bleeding disorders
- Seizure disorders
- History of mania or hypomania
D-Force should be used with caution in patients with a history of substance abuse or dependence.
Storage
D-Force should be stored at room temperature (20-25°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Conclusion
D-Force is an effective medication for the treatment of premature ejaculation, providing men with improved control over ejaculation and enhancing sexual satisfaction. Manufactured by Zenit Pharma, D-Force contains dapoxetine, a selective serotonin reuptake inhibitor that helps delay ejaculation reflex and prolong the time to ejaculation. With proper dosage and adherence to prescribed guidelines, D-Force can significantly improve the quality of sexual life for men experiencing premature ejaculation. Always consult with a healthcare professional before starting any new medication to ensure it is suitable for individual health needs and to discuss potential side effects or interactions.
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