Overview
Tilidin 20x 100/8mg is a prescription medication manufactured by Sandoz, designed for effective pain management. It contains Tilidine, a potent opioid analgesic, and Naloxone, an opioid antagonist. This combination is formulated to provide significant pain relief while minimizing the risk of opioid misuse and dependence.
Composition
Each tablet of Tilidin 20x 100/8mg contains:
- Tilidine: 100 mg
- Naloxone: 8 mg
Other inactive ingredients may include binders, fillers, and coloring agents used to ensure tablet stability and ease of ingestion.
Mechanism of Action
- Tilidine: Tilidine is an opioid analgesic that works by binding to opioid receptors in the central nervous system, altering the perception of and response to pain. It helps in managing moderate to severe pain effectively.
- Naloxone: Naloxone is included to counteract the effects of Tilidine if misused. It acts as an opioid antagonist, blocking the opioid receptors and thereby preventing the euphoric effects of Tilidine when taken in excess or via routes other than prescribed.
Indications
Tilidin 20x 100/8mg is indicated for the treatment of:
- Moderate to severe pain, where the use of an opioid analgesic is appropriate and other pain management strategies are insufficient.
Dosage and Administration
- The typical dosage is determined by a healthcare professional based on the patient’s condition, severity of pain, and response to treatment.
- Tablets should be taken orally, with or without food, as directed by the physician.
- It is crucial to follow the prescribed dosage regimen to minimize the risk of dependency and adverse effects.
Contraindications
- Hypersensitivity to Tilidine, Naloxone, or any other component of the medication.
- Patients with severe respiratory depression or acute asthma.
- Individuals with gastrointestinal obstruction, including paralytic ileus.
Warnings and Precautions
- Addiction, Abuse, and Misuse: Despite the presence of Naloxone, there is still a risk of opioid addiction, abuse, and misuse. Monitor patients closely for signs of abuse and addiction.
- Respiratory Depression: Serious, life-threatening, or fatal respiratory depression may occur. Monitor for respiratory depression, especially during the initiation of treatment or following a dosage increase.
- Risk from Concomitant Use with Benzodiazepines or Other CNS Depressants: Profound sedation, respiratory depression, coma, and death may result from the concomitant use of opioids with benzodiazepines or other CNS depressants.
Side Effects
Common side effects may include:
- Nausea and vomiting
- Dizziness or light-headedness
- Constipation
- Sweating
Severe side effects requiring immediate medical attention:
- Severe respiratory depression
- Severe hypotension
- Serotonin syndrome (if taken with serotonergic drugs)
- Adrenal insufficiency
- Anaphylactic reactions
Storage
- Store at room temperature away from moisture, heat, and light.
- Keep out of reach of children.
Packaging
Tilidin 20x 100/8mg is available in blister packs containing 20 tablets each, ensuring the medication is protected from environmental factors and easy to dispense.
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