Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
MALEGRA-200
Introduction: MALEGRA-200 is a potent medication specifically formulated to treat erectile dysfunction (ED) in men. Containing Sildenafil Citrate as its active ingredient, MALEGRA-200 is recognized for its effectiveness and reliability in helping men achieve and maintain a firm erection, thus enhancing their sexual performance and confidence. Manufactured by Sunrise Remedies, a reputable pharmaceutical company known for producing high-quality medications, MALEGRA-200 stands out in the market due to its high dosage and proven results.
Active Ingredient: The active ingredient in MALEGRA-200 is Sildenafil Citrate, a phosphodiesterase type 5 (PDE5) inhibitor. Sildenafil Citrate works by increasing blood flow to the penis during sexual stimulation, facilitating the achievement and maintenance of an erection. By inhibiting the PDE5 enzyme, Sildenafil ensures that the blood vessels in the penis remain dilated, promoting a sustained erection suitable for sexual intercourse.
Dosage Form and Strength: MALEGRA-200 is available in tablet form, with each tablet containing 200mg of Sildenafil Citrate. This high-dosage formulation is designed for individuals who require a stronger dose to experience optimal results. The medication is presented in a pack of 10 tablets, making it convenient for regular use as prescribed by a healthcare provider.
Indications: MALEGRA-200 is primarily indicated for the treatment of erectile dysfunction (ED) in adult men. Erectile dysfunction is a common condition characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. MALEGRA-200 can also be prescribed for other conditions as determined by a healthcare professional.
Mechanism of Action: Upon sexual stimulation, the release of nitric oxide (NO) in the corpus cavernosum of the penis leads to the activation of the enzyme guanylate cyclase. This enzyme increases levels of cyclic guanosine monophosphate (cGMP), resulting in smooth muscle relaxation and increased blood flow to the penis. Sildenafil Citrate, the active component of MALEGRA-200, enhances the effects of nitric oxide by inhibiting PDE5, which is responsible for the degradation of cGMP in the corpus cavernosum. Consequently, the increased levels of cGMP lead to improved erectile function.
Administration and Dosage: The recommended starting dose of MALEGRA-200 is one 200mg tablet taken approximately 30 to 60 minutes before sexual activity. The tablet should be swallowed whole with a glass of water. It is important to note that sexual stimulation is required for the medication to be effective. The maximum recommended dosing frequency is once per day. Adjustments to the dosage should only be made under the guidance of a healthcare provider.
Contraindications: MALEGRA-200 should not be used in individuals with known hypersensitivity to Sildenafil Citrate or any of the excipients in the tablet. It is also contraindicated in patients who are using nitrates or nitric oxide donors, as the combination can lead to a dangerous drop in blood pressure. Men who have been advised against sexual activity due to cardiovascular risk factors should not use MALEGRA-200.
Precautions: Before starting treatment with MALEGRA-200, a thorough medical assessment is essential to determine the underlying cause of erectile dysfunction and to identify any potential health risks. Caution should be exercised in patients with cardiovascular disease, renal or hepatic impairment, anatomical deformation of the penis, or a predisposition to priapism (painful erections lasting longer than 4 hours). Patients should inform their healthcare provider of all medications they are currently taking, as certain drugs can interact with Sildenafil Citrate.
Side Effects: Like all medications, MALEGRA-200 can cause side effects. Common side effects include headaches, flushing, indigestion, nasal congestion, dizziness, and visual disturbances. These side effects are generally mild and transient. However, if any severe or persistent side effects occur, such as chest pain, sudden vision loss, or an erection lasting more than 4 hours, medical attention should be sought immediately.
Drug Interactions: MALEGRA-200 can interact with certain medications, which may affect its efficacy or increase the risk of adverse effects. Notable interactions include:
- Nitrates: Concurrent use can cause severe hypotension.
- Alpha-blockers: Can lead to symptomatic hypotension.
- Antifungal and antibiotic medications: Certain drugs like ketoconazole and erythromycin can increase Sildenafil levels in the blood.
- Other PDE5 inhibitors or ED treatments: Combining with other ED medications can increase the risk of side effects.
Storage: MALEGRA-200 should be stored in a cool, dry place, away from direct sunlight and moisture. Keep the tablets out of reach of children and pets. The medication should be kept in its original packaging until ready for use to protect it from damage.
Conclusion: MALEGRA-200 is a highly effective treatment for erectile dysfunction, offering a robust solution for men who require a higher dosage of Sildenafil Citrate. Manufactured by Sunrise Remedies, MALEGRA-200 ensures quality, efficacy, and safety, helping men regain their sexual confidence and improve their quality of life. As with any medication, it is crucial to use MALEGRA-200 under the supervision of a healthcare provider to ensure the best possible outcomes and to minimize the risk of adverse effects.
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