Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
SUHAGRA-100
Overview
SUHAGRA-100 is a pharmaceutical product designed to treat erectile dysfunction (ED) in men. Manufactured by Cipla, a renowned name in the pharmaceutical industry, this medication contains 100 mg of the active substance Sildenafil Citrate, which is widely recognized for its efficacy in improving sexual performance and treating ED. Each pack of SUHAGRA-100 contains four tablets, each with 100 mg of Sildenafil, providing a convenient dosage for individuals requiring treatment.
Active Substance: Sildenafil Citrate
Sildenafil Citrate, the active ingredient in SUHAGRA-100, is a potent phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing the blood vessels in the penis, allowing for increased blood flow during sexual arousal. This mechanism helps men achieve and maintain an erection sufficient for sexual activity. Sildenafil Citrate is well-researched and has a strong safety profile, making it a reliable choice for treating ED.
Mechanism of Action
Sildenafil Citrate’s primary action is to inhibit the PDE5 enzyme, which is responsible for the degradation of cyclic guanosine monophosphate (cGMP). During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum of the penis. NO activates the enzyme guanylate cyclase, resulting in increased levels of cGMP. Elevated cGMP levels cause smooth muscle relaxation and increased blood flow into the penile tissue, leading to an erection. By inhibiting PDE5, Sildenafil Citrate ensures that cGMP levels remain high, facilitating prolonged and improved erectile function.
Indications and Usage
SUHAGRA-100 is indicated for the treatment of erectile dysfunction in adult men. Erectile dysfunction is characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. SUHAGRA-100 should be taken approximately 30-60 minutes before sexual activity. The onset of action can vary, but Sildenafil Citrate typically takes effect within 30 to 60 minutes, with peak plasma concentrations achieved within an hour. The effects can last for up to 4 hours, providing ample time for sexual intercourse.
Dosage and Administration
The recommended dosage of SUHAGRA-100 is one tablet (100 mg) taken as needed. It is important to note that the maximum recommended dosing frequency is once per day. The tablet should be swallowed whole with water and can be taken with or without food. However, a high-fat meal may delay the onset of action. Patients are advised not to exceed the prescribed dose and to consult with their healthcare provider if they have any questions or concerns about the medication.
Contraindications
SUHAGRA-100 is contraindicated in individuals with a known hypersensitivity to Sildenafil Citrate or any of the excipients in the formulation. It should not be used by men who are advised against sexual activity due to cardiovascular risk factors. Additionally, it is contraindicated in patients taking nitrates or nitric oxide donors (such as amyl nitrite) in any form, as the combination can lead to severe hypotension.
Precautions and Warnings
Before using SUHAGRA-100, patients should undergo a thorough medical evaluation to determine if their condition is suitable for treatment with Sildenafil Citrate. Certain medical conditions may require dose adjustments or special monitoring. These conditions include:
- Cardiovascular disease
- Renal impairment
- Hepatic impairment
- Anatomical deformation of the penis (e.g., Peyronie’s disease)
- Predisposition to priapism (e.g., sickle cell anemia, multiple myeloma, leukemia)
Patients should be advised that SUHAGRA-100 does not protect against sexually transmitted infections (STIs) or serve as a form of contraception.
Side Effects
Common side effects of SUHAGRA-100 include headache, flushing, dyspepsia (indigestion), nasal congestion, dizziness, and visual disturbances (e.g., changes in color vision, blurred vision). These side effects are generally mild to moderate and transient. However, patients should seek immediate medical attention if they experience any of the following serious side effects:
- Sudden vision loss in one or both eyes
- Sudden hearing loss or tinnitus
- Chest pain or palpitations
- Prolonged or painful erection lasting more than 4 hours (priapism)
Drug Interactions
Sildenafil Citrate can interact with several medications, potentially leading to adverse effects. Patients should inform their healthcare provider of all the medications they are currently taking, including:
- Nitrates or nitric oxide donors
- Alpha-blockers
- Antihypertensives
- Protease inhibitors (used in HIV treatment)
- Other PDE5 inhibitors or erectile dysfunction treatments
Co-administration with these drugs may require dose adjustments or close monitoring to prevent adverse interactions.
Storage and Handling
SUHAGRA-100 tablets should be stored at room temperature, away from moisture and heat. Keep the medication out of reach of children and pets. Do not use the tablets past their expiration date, which is clearly marked on the packaging. Dispose of any unused or expired medication according to local regulations.
Conclusion
SUHAGRA-100 by Cipla is a highly effective and reliable medication for the treatment of erectile dysfunction in men. With its active substance, Sildenafil Citrate, it provides a proven solution to enhance sexual performance and improve quality of life. By inhibiting PDE5 and promoting increased blood flow to the penis, SUHAGRA-100 helps men achieve and maintain satisfactory erections. Patients should follow their healthcare provider’s instructions regarding dosage and administration and be aware of potential side effects and drug interactions. With proper use, SUHAGRA-100 can significantly improve erectile function and restore confidence in men affected by ED.
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