Chemical name: 1-((3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate
Formula: C28H38N6O11S
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
SUHAGRA-50
Overview
Suhagra-50 is a widely recognized and trusted medication primarily used for the treatment of erectile dysfunction (ED) in men. Manufactured by Cipla, a leading pharmaceutical company, Suhagra-50 contains Sildenafil Citrate as its active ingredient. Each pack of Suhagra-50 contains four pills, with each pill containing 50 mg of Sildenafil. This medication is known for its efficacy, safety, and affordability, making it a popular choice among patients and healthcare providers.
Active Ingredient: Sildenafil Citrate
Sildenafil Citrate is a phosphodiesterase type 5 (PDE5) inhibitor. It works by relaxing the blood vessels in the penis, thereby increasing blood flow during sexual stimulation. This mechanism helps men achieve and maintain an erection sufficient for sexual intercourse. Sildenafil Citrate is the same active ingredient found in the well-known brand Viagra, but Suhagra-50 offers a cost-effective alternative without compromising on quality or effectiveness.
Indications
Suhagra-50 is primarily indicated for the treatment of erectile dysfunction (ED). Erectile dysfunction, also known as impotence, is the inability to achieve or maintain an erection suitable for sexual activity. This condition can be caused by various factors, including psychological issues, medical conditions, or certain medications. Suhagra-50 helps to improve erectile function, thereby enhancing sexual performance and confidence.
Dosage and Administration
Dosage: The recommended dose of Suhagra-50 is one 50 mg tablet taken as needed. It should be taken approximately 30 minutes to one hour before sexual activity. However, the onset of action may vary from person to person, and it can be taken anywhere from 30 minutes to 4 hours before sexual activity.
Administration: Suhagra-50 should be swallowed whole with a glass of water. It can be taken with or without food, but taking it on an empty stomach may enhance its effectiveness. It is important not to take more than one tablet in a 24-hour period.
Mechanism of Action
Suhagra-50 works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). PDE5 is responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. cGMP is a substance that promotes the relaxation of smooth muscles and increased blood flow to the penis. By inhibiting PDE5, Suhagra-50 enhances the effect of nitric oxide (NO) released during sexual stimulation, which leads to increased levels of cGMP and improved erectile function.
Pharmacokinetics
- Absorption: Sildenafil Citrate is rapidly absorbed, with peak plasma concentrations reached within 30 to 120 minutes of oral dosing.
- Distribution: The mean steady-state volume of distribution (Vss) for Sildenafil is 105 L, indicating extensive tissue distribution.
- Metabolism: Sildenafil is metabolized predominantly by hepatic enzymes, mainly CYP3A4 and to a lesser extent by CYP2C9.
- Excretion: The terminal half-life of Sildenafil is approximately 4 hours. It is excreted as metabolites predominantly in the feces (approximately 80% of the administered dose) and to a lesser extent in the urine (approximately 13% of the administered dose).
Side Effects
Suhagra-50 is generally well-tolerated, but like all medications, it may cause side effects in some individuals. Common side effects include:
- Headache
- Flushing
- Dyspepsia (indigestion)
- Nasal congestion
- Dizziness
- Visual disturbances (such as changes in color vision, blurred vision)
Most side effects are mild to moderate in nature and usually resolve on their own. However, if any side effects persist or become bothersome, it is important to consult a healthcare provider.
Precautions and Warnings
- Contraindications: Suhagra-50 should not be used by individuals who are allergic to Sildenafil or any other component of the tablet. It is also contraindicated in patients taking nitrates or nitric oxide donors, as the combination can lead to a severe drop in blood pressure.
- Cardiovascular Risk: Patients with cardiovascular disease or those at risk of cardiovascular events should use Suhagra-50 with caution. Sexual activity may pose a risk in patients with heart conditions.
- Priapism: Prolonged erections lasting more than 4 hours (priapism) can occur with PDE5 inhibitors, including Suhagra-50. This condition requires immediate medical attention to prevent damage to the penile tissue.
- Other Conditions: Caution is advised for patients with anatomical deformation of the penis, such as Peyronie’s disease, or those with conditions predisposing to priapism, such as sickle cell anemia, multiple myeloma, or leukemia.
Drug Interactions
Suhagra-50 can interact with certain medications, which may affect its efficacy or increase the risk of adverse effects. It is important to inform the healthcare provider of all medications being taken, including:
- Nitrates: Concurrent use with nitrates or nitric oxide donors is contraindicated due to the risk of severe hypotension.
- Alpha-blockers: Co-administration with alpha-blockers may lead to symptomatic hypotension in some patients.
- CYP3A4 inhibitors: Drugs that inhibit the enzyme CYP3A4 (e.g., ketoconazole, erythromycin, ritonavir) can increase Sildenafil levels, potentially leading to increased side effects.
- CYP3A4 inducers: Drugs that induce CYP3A4 (e.g., rifampicin) can decrease Sildenafil levels, potentially reducing its effectiveness.
Special Populations
- Elderly: Dose adjustments are not required in elderly patients, but caution is advised due to the potential for increased sensitivity to the drug.
- Renal Impairment: No dose adjustment is necessary for patients with mild to moderate renal impairment. For severe renal impairment, a lower dose may be considered.
- Hepatic Impairment: No dose adjustment is necessary for patients with mild to moderate hepatic impairment. For severe hepatic impairment, a lower dose may be considered.
Storage
Suhagra-50 should be stored in its original packaging, away from moisture and heat, at a temperature between 15°C and 30°C (59°F and 86°F). Keep out of reach of children.
Conclusion
Suhagra-50 is a reliable and effective treatment for erectile dysfunction, offering a cost-effective solution for men seeking to improve their sexual health and quality of life. With its well-established safety profile and efficacy, Suhagra-50 continues to be a preferred choice for both patients and healthcare providers. As with any medication, it is important to use Suhagra-50 under the guidance of a healthcare professional to ensure safe and optimal results.
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