Chemical name: (6R-trans)-6-(1,3-benzodioxol-5-yl)- 2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1′, 2′
Formula: C22H19N3O4
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
MEGALIS-10
Overview: MEGALIS-10 is a medication used primarily for the treatment of erectile dysfunction (ED) in men. It contains Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, which works by increasing blood flow to the penis during sexual stimulation. This helps men achieve and maintain an erection suitable for sexual activity.
Active Ingredient: Each tablet of MEGALIS-10 contains 10 mg of Tadalafil.
Manufacturer: MEGALIS-10 is manufactured by Macleods Pharmaceuticals Ltd., a reputable pharmaceutical company known for its high-quality medications.
Indications: MEGALIS-10 is prescribed for the treatment of erectile dysfunction (ED) in adult men. It is not intended for use by women or children under 18 years old.
Mechanism of Action: Tadalafil, the active ingredient in MEGALIS-10, belongs to a class of drugs known as PDE5 inhibitors. During sexual stimulation, nitric oxide is released into the erectile tissue of the penis, which activates the enzyme guanylate cyclase. This enzyme increases levels of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscles in the blood vessels of the penis. This relaxation allows increased blood flow, leading to an erection.
Dosage and Administration: MEGALIS-10 tablets are typically taken orally with a glass of water. The recommended starting dose is one 10 mg tablet taken at least 30 minutes before anticipated sexual activity. Depending on individual response and tolerability, the dose may be increased to 20 mg or decreased to 5 mg. It is not recommended to take more than one dose per day. MEGALIS-10 may be taken with or without food.
Contraindications: MEGALIS-10 is contraindicated in patients with a known hypersensitivity to Tadalafil or any inactive ingredients present in the formulation. It should not be used concurrently with nitrates or nitric oxide donors due to the potential for severe hypotension. Patients with severe hepatic impairment or end-stage renal disease requiring dialysis should also avoid MEGALIS-10.
Adverse Effects: Common side effects of MEGALIS-10 include headache, flushing, dyspepsia, nasal congestion, and back pain. These effects are usually mild to moderate in nature and transient. Rare but serious adverse reactions may include prolonged erections (priapism) or sudden loss of vision or hearing. Patients experiencing any severe or persistent side effects should seek medical attention immediately.
Storage: MEGALIS-10 should be stored at room temperature (25°C) in a dry place away from direct sunlight and moisture. Keep out of reach of children and pets.
Precautions: Patients should inform their healthcare provider of any medical conditions they have and any medications they are currently taking, especially other medications for erectile dysfunction. Grapefruit and grapefruit juice may interact with Tadalafil, so they should be avoided while taking MEGALIS-10.
Conclusion: MEGALIS-10 is a reliable treatment option for men suffering from erectile dysfunction, offering an effective and well-tolerated solution with the convenience of on-demand dosing. It is manufactured by Macleods Pharmaceuticals Ltd., ensuring quality and consistency in each tablet.
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