Chemical name: (6R-trans)-6-(1,3-benzodioxol-5-yl)- 2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1′, 2′
Formula: C22H19N3O4
Anabolic activity index: not a steroid
Androgenic activity index: not a steroid
VIDALISTA-2.5
Overview
Vidalista-2.5 is a pharmaceutical medication that contains the active ingredient Tadalafil, a well-known compound used for the treatment of erectile dysfunction (ED). Manufactured by Centurion Laboratories, Vidalista-2.5 provides a low-dose option for men seeking a reliable solution to enhance their sexual performance and manage symptoms of ED. Tadalafil is a selective inhibitor of phosphodiesterase type 5 (PDE5), an enzyme that regulates blood flow in the penis. By inhibiting PDE5, Vidalista-2.5 facilitates the relaxation of smooth muscles and improves blood circulation, resulting in a firmer and longer-lasting erection when sexually stimulated.
Composition and Mechanism of Action
Each tablet of Vidalista-2.5 contains 2.5 mg of Tadalafil, the active ingredient. Tadalafil is a potent vasodilator that works by inhibiting the PDE5 enzyme in the corpus cavernosum of the penis. The inhibition of PDE5 prevents the degradation of cyclic guanosine monophosphate (cGMP), a molecule responsible for relaxing smooth muscle tissues. When cGMP levels increase, the smooth muscles in the penile arteries relax, leading to enhanced blood flow. This physiological change enables men with ED to achieve and maintain an erection sufficient for sexual intercourse.
Indications
Vidalista-2.5 is primarily indicated for the treatment of erectile dysfunction (ED) in men. ED is characterized by the inability to achieve or maintain an erection suitable for satisfactory sexual performance. Vidalista-2.5 can be an effective treatment option for men who experience ED due to various causes, including psychological stress, diabetes, cardiovascular conditions, or other underlying health issues. Additionally, because of its low dosage, Vidalista-2.5 may be suitable for men who prefer a milder effect or have been prescribed a lower starting dose.
Dosage and Administration
The recommended starting dose of Vidalista-2.5 for most patients is one tablet (2.5 mg) taken orally once per day, at the same time each day, regardless of sexual activity. It is crucial to follow the prescribing doctor’s instructions regarding the dosage. The effect of Vidalista-2.5 can last up to 36 hours, allowing for spontaneity in sexual activity. Patients are advised not to take more than the prescribed dose in a 24-hour period. The tablet should be swallowed whole with a glass of water, and it can be taken with or without food.
Pharmacokinetics
Tadalafil is rapidly absorbed after oral administration, with peak plasma concentrations reached within 30 to 120 minutes. The bioavailability of Tadalafil is not significantly affected by food intake, allowing for flexible dosing relative to meals. Tadalafil has a relatively long half-life of approximately 17.5 hours, which supports its prolonged effect of up to 36 hours. The drug is primarily metabolized by the liver enzyme CYP3A4 and is excreted as inactive metabolites predominantly in the feces and, to a lesser extent, in the urine.
Side Effects
Like all medications, Vidalista-2.5 may cause side effects, although not everyone experiences them. Common side effects include headache, indigestion, back pain, muscle aches, flushing, and nasal congestion. These side effects usually resolve within a few hours to a couple of days. Rare but serious side effects include sudden vision loss, sudden hearing loss, and priapism (a prolonged erection lasting more than four hours). Patients experiencing any severe or persistent side effects should seek immediate medical attention.
Contraindications and Precautions
Vidalista-2.5 is contraindicated in patients who are allergic to Tadalafil or any of the other ingredients in the tablet. It should not be used by individuals taking nitrates for chest pain or those using guanylate cyclase stimulators for pulmonary hypertension, as the combination can lead to a dangerous drop in blood pressure. Caution is advised for patients with cardiovascular conditions, severe kidney or liver impairment, retinitis pigmentosa, or those who have had a recent stroke or heart attack.
Before starting Vidalista-2.5, patients should inform their healthcare provider about their complete medical history and any medications they are currently taking, including over-the-counter drugs, supplements, and herbal products. This is to ensure no potential interactions or contraindications exist that could harm the patient.
Drug Interactions
Tadalafil may interact with other medications, leading to adverse effects or reduced efficacy. Notable drug interactions include:
- Nitrates: Concurrent use with nitrates (e.g., nitroglycerin, isosorbide dinitrate) is strictly contraindicated due to the risk of severe hypotension.
- Alpha-Blockers: Caution is advised when using alpha-blockers (e.g., doxazosin, tamsulosin) for benign prostatic hyperplasia (BPH) as the combination may cause symptomatic hypotension.
- Antihypertensive Drugs: While generally safe, combining Tadalafil with other antihypertensive medications may require dosage adjustments.
- CYP3A4 Inhibitors: Strong inhibitors of CYP3A4 (e.g., ketoconazole, ritonavir) can increase Tadalafil levels, necessitating dose adjustments to avoid toxicity.
- Other PDE5 Inhibitors: Concurrent use with other PDE5 inhibitors is not recommended due to the increased risk of adverse effects.
Storage
Vidalista-2.5 should be stored in its original packaging at room temperature, away from moisture, heat, and direct sunlight. It should be kept out of reach of children and pets to prevent accidental ingestion. The tablets should not be used beyond their expiration date.
Conclusion
Vidalista-2.5 is a low-dose, effective, and reliable treatment option for men with erectile dysfunction. Its active ingredient, Tadalafil, offers a prolonged effect, making it a convenient choice for those who prefer flexibility in their sexual activity. Manufactured by Centurion Laboratories, a reputable pharmaceutical company, Vidalista-2.5 adheres to high standards of quality and safety. Patients considering this medication should consult with their healthcare provider to determine if it is the right choice for their needs and to receive proper guidance on its use.
By choosing Vidalista-2.5, men can take a proactive step toward enhancing their sexual health and overall well-being.
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