Product Overview
OrliFord-120 is a pharmaceutical product containing Orlistat, an active ingredient widely recognized for its efficacy in managing obesity. Each capsule of OrliFord-120 contains 120 mg of Orlistat, designed to aid individuals in their weight loss journey when used alongside a calorie-restricted diet. Manufactured by Banford, a trusted name in the pharmaceutical industry, OrliFord-120 is formulated to offer a reliable solution for those looking to achieve and maintain a healthy weight.
Active Ingredient: Orlistat
Orlistat is a lipase inhibitor that works by preventing the absorption of dietary fats in the intestine. It specifically targets the enzyme lipase, which is responsible for breaking down fats in the digestive system. By inhibiting this enzyme, Orlistat reduces the amount of fat absorbed by the body, allowing it to pass through the digestive system and be excreted. This mechanism helps to lower overall caloric intake, making OrliFord-120 an effective tool in the management of obesity.
Mechanism of Action
Orlistat works locally in the gastrointestinal tract by binding to the active site of gastric and pancreatic lipase. When lipase is inhibited, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids and monoglycerides, reducing calorie absorption. Unlike other weight loss medications that affect the central nervous system, OrliFord-120 does not suppress appetite or increase metabolism. Instead, it provides a targeted approach to reducing fat absorption, making it suitable for a wide range of individuals, including those with certain medical conditions that may preclude the use of other weight loss medications.
Indications
OrliFord-120 is indicated for use in conjunction with a reduced-calorie diet for the treatment of obesity. It is particularly effective for individuals with a body mass index (BMI) of 30 or higher, or those with a BMI of 27 or higher who have other risk factors such as hypertension, diabetes, or hyperlipidemia. OrliFord-120 can also be used to prevent weight regain after previous weight loss.
Dosage and Administration
The recommended dosage of OrliFord-120 is one 120 mg capsule taken orally with water three times a day, during or within one hour of a main meal containing fat. If a meal is missed or contains no fat, the dose of OrliFord-120 can be omitted. It is important to adhere to a nutritionally balanced, reduced-calorie diet that contains approximately 30% of calories from fat. The daily intake of fat, carbohydrates, and protein should be distributed over three main meals.
Pharmacokinetics
Orlistat has minimal systemic absorption, with most of the drug remaining in the gastrointestinal tract. The absorbed fraction is metabolized primarily within the gastrointestinal wall, with the majority of the absorbed drug being excreted in feces. The pharmacokinetics of Orlistat make it a relatively safe option for long-term use, with minimal systemic side effects.
Efficacy
Clinical studies have demonstrated that OrliFord-120 can significantly enhance weight loss when used in combination with a reduced-calorie diet. Patients taking OrliFord-120 typically lose 5-10% of their body weight within six months of treatment, with some achieving even greater weight loss. Additionally, OrliFord-120 has been shown to improve obesity-related risk factors, including reducing waist circumference, lowering blood pressure, and improving cholesterol levels.
Side Effects
The most common side effects of OrliFord-120 are gastrointestinal in nature, reflecting its mechanism of action. These include oily spotting, flatulence with discharge, urgent bowel movements, and fatty or oily stools. These side effects are generally mild and transient, and they often decrease in frequency with continued use. Patients can minimize side effects by adhering to a low-fat diet.
Other possible side effects include headaches, upper respiratory infections, and abdominal pain. Rare but serious side effects include liver injury, kidney stones, and hypersensitivity reactions. Patients should be advised to seek medical attention if they experience symptoms such as jaundice, severe abdominal pain, or difficulty breathing.
Contraindications
OrliFord-120 is contraindicated in patients with chronic malabsorption syndrome, cholestasis, or hypersensitivity to Orlistat or any of the excipients in the formulation. It should also not be used by pregnant or breastfeeding women, as weight loss offers no potential benefit to a pregnant woman and may harm the fetus.
Precautions
Before initiating treatment with OrliFord-120, it is important to evaluate patients for potential nutrient deficiencies, particularly in fat-soluble vitamins (A, D, E, and K). Supplementation with a multivitamin containing these vitamins is recommended, and the multivitamin should be taken at least two hours before or after OrliFord-120 to ensure adequate absorption.
Patients with diabetes mellitus, particularly type 2 diabetes, may experience improved glycemic control with weight loss, which could necessitate adjustment of their diabetes medications. Regular monitoring of blood glucose levels is recommended.
Drug Interactions
OrliFord-120 may interact with other medications, potentially altering their effects. Notable interactions include:
- Cyclosporine: Orlistat may reduce plasma levels of cyclosporine. It is recommended to monitor cyclosporine levels more frequently and adjust the dosage as needed.
- Levothyroxine: Orlistat may reduce the absorption of levothyroxine, leading to hypothyroidism. Patients should take levothyroxine and OrliFord-120 at least four hours apart.
- Warfarin and Other Anticoagulants: OrliFord-120 may affect vitamin K absorption, which can alter the effectiveness of anticoagulants. Patients should have their INR monitored closely.
- Fat-soluble Vitamins: OrliFord-120 may reduce the absorption of fat-soluble vitamins (A, D, E, and K). It is recommended to take a multivitamin supplement at least two hours before or after taking OrliFord-120.
Storage and Handling
OrliFord-120 should be stored at room temperature, away from moisture and heat. The capsules should be kept in their original container, tightly closed, and out of reach of children. The product should not be used beyond its expiration date, and any unused or expired medication should be disposed of in accordance with local regulations.
Patient Counseling Information
Patients should be counseled on the importance of adhering to a nutritionally balanced, reduced-calorie diet that is rich in fruits, vegetables, and low-fat foods. They should also be advised on the potential side effects of OrliFord-120 and how to manage them, particularly the gastrointestinal effects. Regular physical activity is recommended to enhance the weight loss effects of OrliFord-120 and to improve overall health.
Patients should be instructed to take OrliFord-120 exactly as prescribed, without exceeding the recommended dosage. They should also be informed of the importance of taking a multivitamin supplement to prevent potential deficiencies in fat-soluble vitamins.
Conclusion
OrliFord-120 (Orlistat Capsules 120 mg) by Banford is a highly effective weight loss aid that offers a targeted approach to reducing fat absorption from the diet. With a well-established safety profile and proven efficacy, OrliFord-120 is an excellent option for individuals struggling with obesity. When used in conjunction with a reduced-calorie diet and regular physical activity, OrliFord-120 can help patients achieve and maintain a healthier weight, improving their overall quality of life.
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