Buy LEVOTIRON 25mcg Tablets (Levothyroxine Sodium) Online

Introduction

Levotiron 25mcg Tablets contain the active ingredient Levothyroxine Sodium, a synthetic form of the thyroid hormone thyroxine (T4). This medication is primarily used in the management of hypothyroidism, a condition in which the thyroid gland does not produce sufficient thyroid hormones. Levotiron is a trusted brand produced by Abdi İbrahim, a leading pharmaceutical company renowned for its high-quality products.

What is Levothyroxine Sodium?

Levothyroxine Sodium is a synthetic thyroid hormone identical to the naturally occurring hormone produced by the thyroid gland. Thyroxine (T4) is converted into triiodothyronine (T3), which is the active form of the hormone that regulates various metabolic processes in the body. The hormone plays a crucial role in maintaining normal energy levels, body temperature, and the function of the heart, muscles, and digestive system.

Indications and Usage

Levotiron 25mcg Tablets are indicated for the treatment of various conditions related to thyroid hormone deficiency, including:

1. Primary Hypothyroidism: This occurs when the thyroid gland is underactive and unable to produce adequate levels of thyroid hormones. Symptoms may include fatigue, weight gain, cold intolerance, and depression.
2. Secondary Hypothyroidism: Caused by pituitary gland dysfunction, leading to insufficient stimulation of the thyroid gland.
3. Tertiary Hypothyroidism: Results from hypothalamic dysfunction, leading to inadequate production of thyrotropin-releasing hormone (TRH), which in turn affects the thyroid-stimulating hormone (TSH) and the thyroid gland.
4. Goiter: Levotiron may also be used to prevent and treat goiters (an enlarged thyroid gland) that can occur due to iodine deficiency, autoimmune conditions, or other thyroid disorders.
5. Thyroid Cancer: Following thyroidectomy (removal of the thyroid gland), Levotiron is often prescribed to prevent recurrence of thyroid cancer and to maintain normal hormone levels.
6. Thyroid Suppression Test: Levotiron is used in diagnostic tests to assess the function of the thyroid gland.

Dosage and Administration

Levotiron 25mcg Tablets should be taken orally, usually once daily on an empty stomach, 30 minutes to an hour before breakfast. The exact dosage is determined by the healthcare provider based on the patient’s age, weight, medical condition, laboratory test results, and response to treatment.

Initial Dosage:
For adults, the typical starting dose ranges from 12.5 mcg to 50 mcg daily, with gradual adjustments every 4-6 weeks based on TSH levels and clinical response.

Maintenance Dosage:
The maintenance dose varies depending on the individual, but it typically ranges between 100 mcg and 200 mcg per day.

For elderly patients or those with cardiovascular disease, a lower starting dose is recommended to avoid excessive strain on the heart.

Pediatric Dosage:
For infants and children, the dosage is calculated based on body weight and is adjusted as the child grows. Regular monitoring of thyroid function tests is essential.

Mechanism of Action

Levothyroxine Sodium works by replenishing the deficient thyroid hormone levels in the body, thereby restoring normal metabolic activity. Upon ingestion, Levotiron is absorbed into the bloodstream and converted into T3 in the liver and kidneys. T3 then binds to nuclear receptors, influencing the expression of genes involved in energy metabolism, protein synthesis, and overall growth and development.

Pharmacokinetics

Levothyroxine Sodium has a bioavailability of approximately 40-80%, depending on the gastrointestinal environment and the presence of food. The absorption is maximal in the duodenum and upper jejunum. After oral administration, peak plasma levels are reached within 2-4 hours. The half-life of Levothyroxine is about 6-7 days in euthyroid patients, but it can be shorter in hyperthyroid states and longer in hypothyroid states. The drug is primarily metabolized in the liver and excreted mainly in the urine, with some excretion via the bile.

Precautions and Warnings

1. Cardiovascular Disease: Patients with heart conditions, especially those with coronary artery disease or arrhythmias, should use Levotiron cautiously. A lower starting dose is recommended to minimize the risk of exacerbating heart conditions.
2. Osteoporosis: Long-term use of high doses of Levothyroxine can lead to decreased bone density, particularly in postmenopausal women. Regular monitoring of bone health is advisable.
3. Adrenal Insufficiency: Levotiron should not be used in patients with untreated adrenal insufficiency as it may precipitate an adrenal crisis. Corticosteroids should be administered before initiating Levothyroxine therapy.
4. Diabetes: Levotiron may affect blood sugar levels, necessitating adjustments in diabetes medications.
5. Pregnancy and Lactation: Levotiron is safe for use during pregnancy and breastfeeding. Thyroid hormone requirements often increase during pregnancy, and dosage adjustments may be necessary.
6. Drug Interactions: Levotiron can interact with various medications, including:
   • Antacids and calcium supplements (which can reduce absorption)
   • Warfarin (may enhance anticoagulant effects)
   • Insulin or oral hypoglycemics (may require dose adjustment)
   • Beta-blockers and digoxin (may alter their effectiveness)
7. Allergic Reactions: Though rare, some individuals may experience allergic reactions to Levotiron. Symptoms may include rash, itching, swelling, severe dizziness, and trouble breathing. Immediate medical attention is required in such cases.

Side Effects

Most side effects of Levotiron are dose-related and can be minimized by adjusting the dosage. Common side effects include:

• Mild Side Effects:
  • Headache
  • Insomnia
  • Nervousness
  • Sweating
  • Increased appetite
  • Weight loss
  • Sensitivity to heat
• Serious Side Effects:
  • Chest pain
  • Palpitations
  • Rapid or irregular heartbeat
  • Shortness of breath
  • Tremors
  • Seizures

In cases of overdose, symptoms of hyperthyroidism may occur, such as rapid heart rate, anxiety, and muscle weakness. Immediate medical attention is required.

Monitoring and Follow-up

Regular monitoring of thyroid function tests (TSH, T4, and T3 levels) is crucial to ensure that the dosage is adequate and that the patient is responding well to therapy. Initially, thyroid function tests should be performed every 6-8 weeks after starting or adjusting the dose. Once stable, annual monitoring is usually sufficient unless symptoms suggest a change in thyroid function.

Special Populations

Elderly:
Elderly patients are more sensitive to the effects of Levothyroxine and should be started on a lower dose. Close monitoring is necessary to avoid complications, especially in those with underlying heart disease.

Pediatrics:
Children and infants require careful dose adjustment based on weight, age, and thyroid function tests. Growth and development should be regularly monitored to ensure the effectiveness of therapy.

Pregnancy:
Thyroid hormone levels should be monitored more frequently during pregnancy, as requirements typically increase. Levotiron is safe and essential for fetal development.

Storage Instructions

Levotiron 25mcg Tablets should be stored in a cool, dry place away from light and moisture. The tablets should be kept in their original packaging and out of reach of children. Do not store in the bathroom. Disposal of unused medication should be done according to local regulations.

Why Choose Levotiron 25mcg Tablets by Abdi İbrahim?

Abdi İbrahim is a well-established pharmaceutical company with a reputation for producing high-quality and reliable medications. Levotiron 25mcg Tablets are manufactured under stringent quality control standards, ensuring consistent potency and safety. The company’s commitment to innovation and patient care makes Levotiron a trusted choice for the management of thyroid hormone deficiency.

Conclusion

Levotiron 25mcg Tablets offer an effective solution for individuals with hypothyroidism and related thyroid disorders. By restoring normal thyroid hormone levels, Levotiron helps improve quality of life, energy levels, and overall health. Whether prescribed for primary, secondary, or tertiary hypothyroidism, or for the prevention of goiter or recurrence of thyroid cancer, Levotiron remains a cornerstone in thyroid hormone replacement therapy. With regular monitoring and adherence to prescribed dosages, patients can manage their condition effectively with Levotiron, ensuring optimal metabolic function and well-being.