Description: Letrozole, marketed under the brand name Letrasan, is an oral non-steroidal aromatase inhibitor used primarily for the treatment of hormonally-responsive breast cancer after surgery. It works by reducing the production of estrogen in postmenopausal women, which helps slow or reverse the growth of certain types of breast tumors that require estrogen to grow.
Composition: Each Letrasan 2.5 mg Film Tablet contains 2.5 mg of Letrozole, the active ingredient.
Indications:
- Treatment of postmenopausal women with hormone receptor-positive early breast cancer
- Extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy
- First-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor-unknown locally advanced or metastatic breast cancer
- Treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy
Dosage and Administration:
- The recommended dose is 2.5 mg once daily.
- Tablets should be taken orally, with or without food.
- Treatment duration and dosage may vary based on individual patient factors and the specific type and stage of breast cancer being treated.
Contraindications:
- Letrozole is contraindicated in premenopausal women.
- Hypersensitivity to letrozole or any component of the formulation.
Warnings and Precautions:
- Letrozole may cause fetal harm if administered to pregnant women.
- Patients should be monitored for bone mineral density changes during therapy.
- Hepatic impairment may require dosage adjustments.
Storage: Store at room temperature (15-30°C). Protect from light and moisture.
Adverse Reactions: Common adverse reactions include hot flashes, joint pain, fatigue, nausea, and osteoporosis.
Legal Status: Prescription-only medication.
Packaging: Letrasan (Letrozol) 2.5 mg Film Tablets are supplied in blister packs of 30 tablets.
Manufacturer Information: Manufactured by DEVA Pharmaceuticals, known for their commitment to quality and adherence to international manufacturing standards.
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