Kerendia (finerenone) is a nonsteroidal mineralocorticoid receptor antagonist (MRA) approved by the US Food and Drug Administration (FDA) to reduce the risk of kidney failure, cardiovascular death, heart attack, and hospitalization for heart failure in adults with chronic kidney disease (CKD) associated with type 2 diabetes (T2D).
How does Kerendia work?
Kerendia works by blocking the mineralocorticoid receptor (MR), which is activated by the hormone aldosterone. Aldosterone is released by the adrenal glands and plays a role in regulating blood pressure and fluid levels in the body. However, too much aldosterone can damage the kidneys and heart.
Kerendia blocks the MR from being activated, which can help to protect the kidneys and heart from damage.
Who should take Kerendia?
Kerendia is approved for adults with CKD associated with T2D who have moderate or severe kidney damage and who pass albumin (a type of protein) in their urine.
How is Kerendia taken?
Kerendia is taken once daily as a tablet. The dose is based on the patient’s kidney function.
What are the side effects of Kerendia?
The most common side effects of Kerendia are:
- Hyperkalemia (high potassium levels)
- Hypotension (low blood pressure)
- Hypovolemia (low blood volume)
- Diarrhea
- Fatigue
- Dizziness
- Headache
- Back pain
Other, more serious side effects of Kerendia can occur, such as acute kidney injury and liver injury.
Important safety information
Kerendia should not be taken by patients with:
- Severe hyperkalemia
- Severe hypotension
- Severe hypovolemia
- Addison’s disease (a condition in which the adrenal glands do not produce enough hormones)
- Pregnancy
- Breastfeeding
Kerendia should be used with caution in patients with:
- Mild or moderate hyperkalemia
- Mild or moderate hypotension
- Mild or moderate hypovolemia
- Heart failure
- Liver disease
- Kidney disease
Kerendia can interact with other drugs, such as potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARBs). It is important to tell your doctor about all of the medications you are taking before starting Kerendia.
If you are considering taking Kerendia, talk to your doctor about the risks and benefits of the medication.
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