Entresto is a combination medication that contains sacubitril and valsartan, used to treat heart failure in adults. Sacubitril is a neprilysin inhibitor that helps increase levels of beneficial peptides in the body, while valsartan is an angiotensin II receptor blocker that helps lower blood pressure.
Uses:
Entresto is used to treat chronic heart failure with reduced ejection fraction in adults who have symptoms despite receiving treatment with standard heart failure medications. It helps improve symptoms, reduce hospitalizations and the risk of cardiovascular death.
Storage Conditions:
Entresto should be stored at room temperature between 68°F and 77°F (20°C to 25°C). The medication should be kept in the original container and protected from light and moisture.
Mechanism of Action:
Sacubitril works by inhibiting the enzyme neprilysin which helps increase levels of beneficial peptides such as natriuretic peptides and angiotensin converting enzyme 2, leading to vasodilation and sodium excretion. Valsartan works by blocking the angiotensin II receptor, preventing blood vessels from constricting and reducing blood pressure.
HOW TO USE:
Entresto comes in tablet form and is taken orally twice a day with or without food. The dosage is determined by the healthcare provider and depends on the patient’s medical condition, renal function, and tolerability to the medication. Patients should follow the instructions on the prescription label and use the medication exactly as directed.
Important Safety Information:
• Entresto should not be used by patients who are allergic to sacubitril or valsartan or any of its components, or who have had a previous reaction to an angiotensin-converting enzyme (ACE) inhibitor.
• The medication should not be used during pregnancy as it may harm the fetus.
• The medication may increase the risk of hyperkalemia (high potassium levels) and patients with renal impairment or taking potassium-sparing diuretics should be monitored closely while taking the medication.
• The medication may also cause hypotension (low blood pressure), and patients should be monitored closely for symptoms such as dizziness or fainting.
Indications:
• Entresto is indicated for the treatment of chronic heart failure with reduced ejection fraction in adults who have symptoms despite receiving treatment with standard heart failure medications.
Precautions:
• Patients with a history of angioedema, a serious allergic reaction, should be monitored closely while taking Entresto.
• The medication should be used with caution in patients with a history of liver disease, diabetes, or renal impairment.
Interactions:
• The medication may interact with other medications such as potassium-sparing diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs).
• Patients taking other medications that may increase potassium levels, such as ACE inhibitors or potassium supplements, should be closely monitored while taking Entresto.
Contraindications:
• Entresto is contraindicated in patients who are allergic to sacubitril or valsartan or any of its components, or who have had a previous reaction to an ACE inhibitor.
• The medication should not be used during pregnancy and breastfeeding.
Overdose:
In case of an overdose, patients should seek emergency medical attention immediately.
Side Effects:
The most common side effects of Entresto include hypotension, hyperkalemia, cough, and dizziness. Serious side effects may include angioedema, impaired kidney function, and fetal toxicity. Patients should notify their healthcare provider if they experience any unusual symptoms while taking Entresto.
In conclusion, Entresto is a combination medication used to treat chronic heart failure with reduced ejection fraction in adults. It works by inhibiting the enzyme neprilysin and blocking the angiotensin II receptor, leading to vasodilation and lower blood pressure. Entresto is taken orally twice a day and the dosage is determined by the healthcare provider. Patients should not use Entresto if they are allergic to sacubitril or valsartan or any of its components or if they have had a previous reaction to an ACE inhibitor. It may cause hyperkalemia, hypotension, and interact with other medications such as potassium-sparing diuretics and NSAIDs. Pregnant women and breastfeeding mothers should not use Entresto. Patients should seek emergency medical attention in case of overdose and notify their healthcare provider of any unusual symptoms.
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